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Found 63 clinical trials
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MRI Study of the Mechanisms Underlying Irreversible Disability in Multiple Sclerosis

of MS is not restricted to the macroscopic lesions of the white matter but also involves the normal appearing white and grey matter. In the normal appearing brain tissue, demyelination, neuronal

demyelination
MRI
nervous
disease or disorder
cognitive deficits
  • 14 views
  • 21 Jan, 2021
  • 2 locations
None
Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis

The objective of this trial is to assess the efficacy and safety of CNM-Au8 as a remyelinating treatment for vision-impairing MS lesions in participants who have chronic vision impairment as a result of Relapsing-Remitting Multiple Sclerosis. The primary endpoint is to assess the efficacy and safety of CNM-Au8 as a …

deficit
diabetic retinopathy
relapsing multiple sclerosis
disease or disorder
  • 39 views
  • 09 May, 2021
  • 17 locations
None
Aerobic Exercise for Remyelination in Multiple Sclerosis

This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).

  • 0 views
  • 16 May, 2021
  • 1 location
None
A Study of AAV9 Gene Therapy in Participants With Canavan Disease

The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.

  • 0 views
  • 22 Aug, 2021
None
Effects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients

with environmental factors (vitamin D deficiency, tobacco, vaccines, stress, diet, ...). MS is a neurological disease in which demyelination and axonal loss lead to many symptoms such as fatigue

  • 0 views
  • 19 Feb, 2021
  • 1 location
None
The Effect of Telerehabilitation Based Pilates Training in Multiple Sclerosis Patients

demyelination of axons in the brain, optic nerve, and spinal cord; over time it develops into a neurodegenerative disease associated with neurotrophic support deficiency and neuronal loss. In MS, various loss

demyelination
weakness
nervous
disease or disorder
myelopathies
  • 0 views
  • 07 Aug, 2021
  • 1 location
None
Safety and Efficacy of Intrathecal Rituximab in Patients With Multiple Sclerosis

Considering the accumulated data on the pathogenesis of multiple sclerosis, indicating a significant role of B cells in the progression of the disease, the use of monoclonal antibodies to CD20 antigen, administered intrathecally to achieve adequate B-lymphodepletion in the barrier tissues can increase the duration of the recurrence-free course of …

disease or disorder
cyclophosphamide
rituximab
  • 0 views
  • 22 Oct, 2021
  • 1 location
None
Enhancing Facial Nerve Function With Omega-3 After Resection of Vestibular Schwannoma

The purpose of this research is to develop a therapeutic agent to help improve facial nerve outcomes and ultimately improve long-term quality-of-life following surgical resection of vestibular schwannomas. It is possible the therapeutic agent may impact tumor control rates as well, and this will also be studied. Using rigorous scientific …

  • 0 views
  • 20 Nov, 2021
  • 1 location
None
A Personalised Radiosurgery Procedure for People With Trigeminal Neuralgia to Improve Pain Quality of Life and Reduce Complications

The aim of this study is to evaluate prospectively the feasibility and impact of personalised gamma knife radiosurgery treatment protocol versus current standard protocol for people with idiopathic or Multiple Sclerosis-related Trigeminal Neurolgia (MS related TN) on effectiveness in pain relief, the development of morbidity and quality of life. Patients …

facial numbness
ache
pain relief
neuralgia
  • 100 views
  • 06 Oct, 2021
  • 1 location
None
Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156 participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy of Best Available Therapy (BAT) for treatment-resistant relapsing multiple sclerosis (MS). Participants will be randomized at a 1 to 1 (1:1) ratio. …

aubagio
natalizumab
relapsing multiple sclerosis
fingolimod
cladribine
  • 354 views
  • 30 Dec, 2021
  • 15 locations