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Found 66 clinical trials
Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis Patients

This is a longitudinal single blind randomized trial to test the effects of high compared to low dose vitamin D3 supplementation on cognitive performance at 6 and 12 months, and MRI measures of 12 months duration. A cognitive assessment battery will be administered at baseline, 6 and 12 months. Related …

depression
vitamin d
MRI
disease or disorder
  • 7 views
  • 12 Feb, 2022
  • 1 location
OTL-200 in Patients With Late Juvenile Metachromatic Leukodystrophy (MLD)

lentiviral vector encoding the human arylsulfatase A (ARSA) gene. MLD is an autosomal recessive lysosomal storage disorder (LSD) characterized by severe and progressive demyelination affecting the central

  • 90 views
  • 28 Feb, 2022
  • 1 location
Electrical Stimulations on Pain, Functional Capacity and Quality of Life in Multiple Sclerosis

Multiple Sclerosis (MS) is a chronic neurological disease with local inflammation, gliosis and demyelination in the central nervous system (CNS). It is characterized by demyelinating plaques in

nervous
demyelination
disease or disorder
neurological disorder
myelopathies
  • 0 views
  • 15 Jul, 2022
  • 1 location
Exercise and Neuroprotection in Older Persons With Multiple Sclerosis

The study seeks to investigate whether 24 weeks of power training has neuroprotective effects in older PwMS. Additional purposes are to examine whether older PwMS have blunted exercise adaptations, compared to age- and gender-matched healthy controls, and to investigate whether the potential effects of power training are maintained after 24 …

  • 0 views
  • 01 Mar, 2021
  • 1 location
Pediatric Patient Experience on a Diagnostic Path

The trial will determine the impact of an information- and education-focused interventions on the anxiety levels, and patients' experiences as well as satisfaction of patients aged 10-14 and their caregivers during the MR examination.

anxiety
x-rays
  • 0 views
  • 24 Mar, 2022
MRI Study of the Mechanisms Underlying Irreversible Disability in Multiple Sclerosis (SEP-MRI)

of MS is not restricted to the macroscopic lesions of the white matter but also involves the normal appearing white and grey matter. In the normal appearing brain tissue, demyelination, neuronal

nervous
demyelination
disease or disorder
MRI
cognitive deficits
  • 14 views
  • 31 Jan, 2022
  • 1 location
Proprioceptive Neuromuscular Facilitation in Multiple Sclerosis

Multiple Sclerosis (MS) is an autoimmune central nervous system disease characterized by inflammation, demyelination, and axonal degeneration. Clinical symptoms of the disease include fatigue

nervous
fatigue
demyelination
disease or disorder
Accepts healthy volunteers
  • 0 views
  • 09 Jul, 2022
  • 1 location
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire)

The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.

  • 0 views
  • 25 Apr, 2022
Effects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients

with environmental factors (vitamin D deficiency, tobacco, vaccines, stress, diet, ...). MS is a neurological disease in which demyelination and axonal loss lead to many symptoms such as fatigue

  • 0 views
  • 19 Feb, 2021
  • 1 location
Safety and Efficacy of Intrathecal Rituximab in Patients With Multiple Sclerosis

Considering the accumulated data on the pathogenesis of multiple sclerosis, indicating a significant role of B cells in the progression of the disease, the use of monoclonal antibodies to CD20 antigen, administered intrathecally to achieve adequate B-lymphodepletion in the barrier tissues can increase the duration of the recurrence-free course of …

cyclophosphamide
disease or disorder
rituximab
  • 0 views
  • 22 Oct, 2021
  • 1 location