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Found 63 clinical trials
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP an Autoimmune Disorder That Affects the Peripheral Nerves)

This is the open-label extension study of phase II ARGX-113-1802 to evaluate the long-term safety and efficacy of the subcutaneous formulation of efgartigimod in adults with CIDP.

polyradiculoneuropathy
autoimmune disease
polyneuropathy
ph20
  • 13 views
  • 06 Dec, 2021
  • 64 locations
A Study to Assess the Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP an Autoimmune Disorder That Affects the Peripheral Nerves)

This is a Phase 2 study to evaluate the safety and efficacy of the subcutaneous formulation of efgartigimod in adults with CIDP.

polyradiculoneuropathy
corticosteroids
ph20
prednisone
polyneuropathy
  • 386 views
  • 05 Dec, 2021
  • 135 locations
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with multiple sclerosis (MS). Hypothesis 1: Administration of [18F]3F4AP will result in no changes …

demyelination
demyelinating disorder
MRI
disease or disorder
  • 0 views
  • 22 May, 2021
  • 1 location
Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Brian Injury

The overall objective is to obtain an initial assessment of the value of using [18F]3F4AP for imaging demyelinating diseases such as traumatic brain injury (TBI), neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's Disease (AD): Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with …

alzheimer's disease
mental state examination
mild cognitive impairment
cognitive impairment
traumatic brain injury
  • 0 views
  • 24 Jan, 2022
  • 1 location
ACT-01 in Patients With Acute Optic Neuritis

To evaluate the safety and tolerability of ACT-01 compared to placebo in patients with acute optic neuritis (AON) receiving the standard of care.

  • 1 views
  • 14 Mar, 2021
  • 2 locations
Application of ihMT MRI in Multiple Sclerosis

The development of in vivo biomarkers sensitive to myelin disruption represents a major clinical need to be able to monitor the demyelination processes as well as the effect of remyelinating

demyelination
disease or disorder
relapsing multiple sclerosis
MRI
brain mri
  • 4 views
  • 22 Aug, 2021
  • 1 location
Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis Patients

This is a longitudinal single blind randomized trial to test the effects of high compared to low dose vitamin D3 supplementation on cognitive performance at 6 and 12 months, and MRI measures of 12 months duration. A cognitive assessment battery will be administered at baseline, 6 and 12 months. Related …

MRI
depression
vitamin d
disease or disorder
  • 7 views
  • 05 Sep, 2021
  • 1 location
OTL-200 in Patients With Late Juvenile Metachromatic Leukodystrophy (MLD)

lentiviral vector encoding the human arylsulfatase A (ARSA) gene. MLD is an autosomal recessive lysosomal storage disorder (LSD) characterized by severe and progressive demyelination affecting the central

  • 82 views
  • 05 Mar, 2021
  • 1 location
Accurate Diagnosis of Multiple Sclerosis Using Hybrid Positron Emission Tomography/Magnetic Resonance (PET/MR)

Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease of the central nervous system. Its main feature is progressive demyelination, which ultimately leads to

  • 0 views
  • 22 Mar, 2021
  • 1 location
Exercise and Neuroprotection in Older Persons With Multiple Sclerosis

The study seeks to investigate whether 24 weeks of power training has neuroprotective effects in older PwMS. Additional purposes are to examine whether older PwMS have blunted exercise adaptations, compared to age- and gender-matched healthy controls, and to investigate whether the potential effects of power training are maintained after 24 …

  • 0 views
  • 01 Mar, 2021
  • 1 location