Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 66 clinical trials
Featured trial
A study of subcutaneous immunoglobulin as chronic treatment for patients with chronic inflammatory demyelinating polyneuropathy

A study of subcutaneous immunoglobulin as chronic treatment for patients with chronic inflammatory demyelinating polyneuropathy

  • 410 views
  • 08 Nov, 2020
  • 1 location
None
Proof-of-concept Study for BIVV020 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Primary Objective: Part A: Efficacy of BIVV020 across three subpopulations of CIDP patients: standard of care (SOC)-Treated, SOC-Refractory and SOC-Naive Part B:Long-term safety and tolerability of BIVV020 in CIDP Secondary Objective: -Part A: Safety and tolerability of BIVV020 in CIDP Immunogenicity of BIVV020 Efficacy of BIVV020 with overlapping SOC (SOC-Treated …

mycophenolate mofetil
immune globulin
immunoglobulin therapy
polyneuropathy
cyclosporine
  • 0 views
  • 03 Dec, 2021
  • 29 locations
None
Cognition Evolution and MRI Markers in PPMS Patients on 2 Years

primary progressive multiple sclerosis (PPMS) as compared with relapsing-remitting MS (RRMS). In PPMS pathological studies have shown the importance of cortical demyelination and meningeal inflammation

Accepts healthy volunteers
  • 0 views
  • 06 Oct, 2021
  • 3 locations
None
TOTEM RRMS : TestOsterone TreatmEnt on Neuroprotection and Myelin Repair in Relapsing Remitting Multiple Sclerosis

precursors into mature oligodendrocytes in a cuprizone-induced animal model of demyelination. The rare clinical trials on testosterone are mainly exploratory. Here, we sought to demonstrate an effect of

demyelination
depression
natalizumab
tysabri
fatigue
  • 25 views
  • 25 Oct, 2021
  • 5 locations
None
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)

The main purpose of this study is to assess clemastine as a remyelinating agent in patients with acute optic neuritis.The study will also evaluate the tolerability of clemastine, originally approved as first-generation antihistamine, in patients with optic neuritis. Study procedures will include assessments for evidence of remyelination in the anterior …

antihistamine
  • 27 views
  • 14 Nov, 2021
  • 1 location
None
Comparision Efficacy of Carbamazepine & Oxcarbazepine in the Treatment of Trigeminal Neuralgia- a Randomised Clinical Trial

Trigeminal neuralgia is a neuropathic facial pain condition, characterized by unilateral paroxysmal pain which can be described as stabbing or electric shock like, in the distribution of one or more divisions of trigeminal nerve which is triggered by innocuous stimuli. The attack is provoked by touching or stimulating these trigger …

ache
oxcarbazepine
carbamazepine
facial pain
Accepts healthy volunteers
  • 9 views
  • 20 Oct, 2021
  • 2 locations
None
Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like …

igiv
polyneuropathy
weakness
plasma exchange
  • 0 views
  • 19 Jul, 2021
  • 1 location
None
Proof-of-concept Study for BIVV020 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Primary Objective: Part A: Efficacy of BIVV020 across three subpopulations of CIDP patients: standard of care (SOC)-Treated, SOC-Refractory and SOC-Naive Part B:Long-term safety and tolerability of BIVV020 in CIDP Secondary Objective: -Part A: Safety and tolerability of BIVV020 in CIDP Immunogenicity of BIVV020 Efficacy of BIVV020 with overlapping SOC (SOC-Treated …

mycophenolate mofetil
immune globulin
immunoglobulin therapy
polyneuropathy
cyclosporine
  • 7 views
  • 11 Jul, 2021
  • 8 locations
None
A First in HumanTrial to Evaluate The Safety Tolerability And Pharmacokinetics Of PF-06755347

This phase 1 single ascending dose study will provide a first in human assessment of safety and tolerability of PF-06755347 in healthy adult male subjects. The pharmacokinetics and pharmacodynamics will also be evaluated.

heart failure
cancer
malignancy
administered intravenously
  • 194 views
  • 29 Sep, 2021
  • 6 locations
None
Long-Term Tolerability and Safety of HYQVIA/HyQvia in CIDP

The purpose of this phase IIIb study is to assess the long-term safety, tolerability, and immunogenicity of the subcutaneous (SC) treatment with Immune Globulin Subcutaneous (IGSC) facilitated with recombinant human hyaluronidase (rHuPH20) (HYQVIA/HyQvia) in participants with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who have completed Baxalta Clinical Study Protocol 161403 Epoch …

igiv
immune globulin
polyradiculoneuropathy
hyqvia
recombinant human hyaluronidase
  • 228 views
  • 26 Sep, 2021
  • 51 locations