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Found 8 clinical trials
Exercise and Neuroprotection in Older Persons With Multiple Sclerosis

The study seeks to investigate whether 24 weeks of power training has neuroprotective effects in older PwMS. Additional purposes are to examine whether older PwMS have blunted exercise adaptations, compared to age- and gender-matched healthy controls, and to investigate whether the potential effects of power training are maintained after 24 …

  • 01 Mar, 2021
  • 1 location
Pediatric Patient Experience on a Diagnostic Path

The trial will determine the impact of an information- and education-focused interventions on the anxiety levels, and patients' experiences as well as satisfaction of patients aged 10-14 and their caregivers during the MR examination.

  • 24 Mar, 2022
Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Brian Injury

The overall objective is to obtain an initial assessment of the value of using [18F]3F4AP for imaging demyelinating diseases such as traumatic brain injury (TBI), neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's Disease (AD): Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with …

mild cognitive impairment
cognitive impairment
traumatic brain injury
neuropsychological assessment
alzheimer's disease
  • 17 May, 2022
  • 1 location
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire)

The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.

  • 25 Apr, 2022
Aerobic Exercise for Remyelination in Multiple Sclerosis

This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).

  • 25 May, 2022
  • 1 location
A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma

The purpose of this study is to evaluate the role of 4-aminopyridine (4-AP) on the course of recovery after peripheral nerve traction and/or crush injury. The investigational treatment will be used to test the hypothesis that 4-aminopyridine speeds the often slow and unpredictable recovery after peripheral nerve traction and/or crush …

  • 24 May, 2022
  • 1 location
Pregnancy Cohort in Multiple Sclerosis (MS)

Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system frequently affecting females in their reproductive phase of life. In this prospective

disease or disorder
demyelinating disorder
clinically isolated syndrome
  • 26 Aug, 2021
  • 1 location
Natural History Study of Patients With Canavan Disease

This study will use medical records that will allow retrospective data extraction of critical milestone and motor function data. In addition, prospective assessments will collect data relevant to the natural history of Canavan disease in children.

  • 14 May, 2022
  • 1 location