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Found 15 clinical trials
Study on Early Brain Injury Mechanism and Comprehensive Intervention of VCI

project is to establish a study cohort of non-demented vascular cognitive impairment(VCIND). Neurocognitive function assessment combined with multimodal MRI including ASL, DCE, DTI and BOLD techniques

  • 26 views
  • 19 Aug, 2021
  • 1 location
The Swedish BioFINDER 2 Study (BioFINDER2)

The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g. to characterize the role of beta-amyloid pathology in early diagnosis of Alzheimer's disease (AD) using amyloid-PET (18F-Flutemetamol) and A analysis in …

tauopathies
amyloid
brain imaging
major neurocognitive disorder
amyloidosis
  • 178 views
  • 25 Feb, 2022
  • 1 location
The Effects of Chicken Extract and a Peptide Supplement for the Prevention of Cognitive Decline in Non-demented Elderly Adults

-demented elderly adults using a three-arm, randomized, placebo-controlled clinical trial design.

Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 3 locations
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

The purpose of this study is to assess the safety, tolerability, immunogenicity and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented

dementia
amyloid
alzheimer's disease
demented
acetylcholinesterase
  • 0 views
  • 07 Oct, 2022
  • 2 locations
tDCS on Parkinson's Disease Cognition (tDCS-PD-fMRI)

relatively slowly progressing cognitive deficits (compared to their motor deficits) have become one of the major challenges. Approximately 80% of PD patients eventually become demented. Therefore cognitive

dementia
brain stimulation
antipsychotics
cognitive assessment
motor symptoms
  • 169 views
  • 20 Apr, 2022
  • 1 location
MRI and PET Biomarkers for Cognitive Decline in Older Adults

The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age. The investigators will test the usefulness of MRI, PET, and cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to this study includes …

dementia
positron emission tomography
Accepts healthy volunteers
amyloid
alzheimer's disease
  • 7 views
  • 24 Jan, 2022
  • 1 location
Taiwan Geriatric Study for Dementia Risk Prevention and Cognitive Enhancement by Multi-modal Intervention (TaiPEI)

A 3-arm randomized controlled trial of multi-modal non-pharmacological Intervention for preventing the risk of dementia in Taiwanese geriatric people

dementia
Accepts healthy volunteers
cognitive decline
mild cognitive impairment
cognitive impairment
  • 0 views
  • 18 Jun, 2022
  • 1 location
The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition (PREVENTION)

The PREVENTION Trial is a 12-month, two-arm randomized clinical trial (RCT) in adults 50-80 years old experiencing cognitive decline. Our study clinicians will refer patients for enrollment based on three categories: 1) a diagnosis of mild AD according to criteria established by the National Institute of Neurological and Communicative Disorders …

positron emission tomography
amyloid
neurodegenerative disorders
cognitive decline
stroke
  • 5 views
  • 28 Jun, 2022
  • 1 location
Personalized tDCS in Elderly Fallers Study

The objective of this study is to determine if a four-week, 20-session intervention of personalized transcranial direct current stimulation (tDCS), as compared to sham intervention, improves dual task standing and walking performance (Aim 1), as well as other physical (Aim 2) and cognitive (Aim 3) factors on the causal pathway …

  • 13 views
  • 04 Oct, 2022
  • 1 location
Cardiovascular Risk Factors and Cognitive Trajectories

The cognitive trajectory varies among non-demented older adults. In a 12-year follow-up study, we found approximately 5% participants presented rapid cognitive decline. Cardiovascular diseases

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location