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Found 202 clinical trials
Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam

In this parallel, multicenter, single-blind randomized controlled trial, mechanical ventilated patients will be randomly assigned to two groups. One receives remimazolam to achieve sedation goals, while the other receives Midazolam. The primary outcome is the effect of remimazolam on duration of mechanical ventilated of critical patients compared to midazolam.

  • 19 Apr, 2022
Sleep Disturbances and Delirium (SLEEP)

Delirium is a frequent and serious problem in hospitalized patients; it is associated with multiple hospital-acquired complications. There is evidence that the incidence of deliri-um may be

sleep disturbances
  • 15 Jun, 2022
  • 1 location
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)

Sleep deprivation is common and severe in critically ill patients cared for in intensive care units (ICUs), and is hypothesized to be a key modifiable risk factor for delirium and long-term

mechanical ventilation
critical illness
  • 04 Mar, 2022
The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery (SKED)

Postoperative delirium (POD) is a common and distressing complication after thoracic surgery. S-ketamine has neuroprotective properties as a dissociative anesthetic. Emerging literature has

  • 04 Oct, 2022
  • 1 location
Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery

Delirium is common in the elderly after hip fracture surgery, and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after hip fracture surgery

  • 08 Dec, 2021
  • 1 location
Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

after TURBT are at risk for recurrence and progression. Benzodiazepines are proved to inhibit proliferation of multiple types of cancer cells in vitro. Delirium is an acute onset and transient cerebral

transurethral bladder excision
bladder tumor
invasive bladder cancer
surgery for bladder cancer
transurethral resection
  • 19 Jul, 2021
  • 6 locations
Dexmedetomidine and Outcomes of Elderly Admitted to ICU After Surgery

Sleep disorder and delirium are common problems in intensive care unit (ICU) patients, and may lead to poor prognosis. The investigators' previous study showed that nighttime infusion of low

  • 23 Sep, 2021
  • 1 location
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients (DELIRLESS)

Postoperative delirium (POD) is one of the most frequent complications after surgery in elderly patients, affecting between 20 and 40% of patients older than 60 after major surgery. This

  • 15 Jul, 2022
  • 1 location
PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients (PANDORA)

Our objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and

heart surgery
bypass graft
coronary artery bypass graft
postoperative delirium
  • 03 Jul, 2022
  • 6 locations
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery (ALPHA2PREVENT)

for the prevention of delirium and cognitive decline in male and female participants aged 70+ scheduled for open heart surgery.

  • 07 Oct, 2022
  • 4 locations