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Found 505 clinical trials
The Effect of Guanfacine on Delirium in Critically Ill Patients

Delirium in patients in the intensive care unit (ICU) is a common problem associated with increased mortality and morbidity, including increased hospital and ICU length of stay, greater hospital cost, increased ventilator days, and long-term cognitive disability. Various pharmacologic agents including dopamine antagonists, acetylcholinesterase inhibitors, melatonin, antipsychotics, alpha-2 agonists, and …

  • 26 Nov, 2021
  • 1 location
Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation

The purpose of this project is to compare a novel sensorimotor ankle rehabilitation training (SMART) protocol for Lateral ankle sprains (LASs) against a standard of care (SOC) protocol to determine if it is more successful at producing successful one-year outcomes and lower rates of re-injury and improved health. This will …

  • 24 Feb, 2022
  • 1 location
Exoskeleton Research: Myoelectric Orthosis for Rehab of Severe Chronic Arm Motor Deficits

This study will evaluate the effects of combining motor learning-based therapy with use of the MyoPro , a wearable exoskeletal myoelectrically controlled orthotic device. MyoPro uses electromyographic (EMG) signals from the weak muscles to assist movement of the user's affected arm. The primary objective of this randomized controlled trial is …

  • 23 Apr, 2022
  • 1 location
Sterile Amniotic Fluid Filtrate Epidural Injection.

There is a large population of patients with lumbosacral radicular pain due to spinal stenosis who do not respond to physical therapy or oral medication management, yet wish to avoid spinal surgery or are simply not candidates due to medical co-morbidity. Given the natural history of lumbar spinal stenosis, these …

  • 06 Jan, 2022
  • 1 location
Dual-task Training in Older Adults

This study seeks to understand what factors influence the capacity to perform simultaneous motor and cognitive tasks in older adults to improve movement throughout their community with the least risk of injury. To function in the real world, one needs to "walk and talk", or to move about the community …

Accepts healthy volunteers
  • 12 Apr, 2022
  • 1 location
Methylphenidate in Adults With Attention Deficit/Hyperactivity Disorder

Methylphenidate (MPH) is the first-line pharmacological treatment for adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Nevertheless, there is considerable interindividual variability

psychiatric disorder
attention deficit disorder
  • 21 Jan, 2021
  • 2 locations
Algeness DF 3.5% Compared to Voluma in Volume Deficit in Mid-face

A prospective, randomized, controlled study of Algeness® DF 3.5% Deep Volumizing Filler comparing to Juvéderm Voluma to correct midface volume loss.

Accepts healthy volunteers
  • 07 Jul, 2022
  • 8 locations
A Study of TAK-503 in Children and Teenagers With Attention Deficit Hyperactivity Disorder (ADHD)

The main aim of this study is learn more about long-term treatment of children and teenagers with ADHD for whom earlier stimulant therapy did not work. The study has two parts (A and B). In Part A, participants will take tablets of TAK-503, atomoxetine or placebo. Participants who take placebo …

attention deficit disorder
beta human chorionic gonadotrophin
  • 04 Oct, 2022
  • 34 locations
A Trial of Centanafadine Long-term Safety in Children and Adolescents With Attention-deficit/Hyperactivity Disorder (ADHD)

The primary purpose of this trial is to evaluate the safety and tolerability of centanafadine QD XR in pediatric subjects with ADHD.

  • 07 Oct, 2022
  • 1 location
A Framework For Linking Sequential Pattern Rules in DLD: Perception in Adults

This broad aim of this clinical study is to assess the hypothesis that morphological and phonological deficits are linked by a broader deficit in sequential pattern learning. This hypothesis

  • 21 Aug, 2021
  • 2 locations