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Found 92 clinical trials
Treatment of Malignant Tumors With Antigen Peptide-specific DC-CTL Cells and Decitabine

Tumor-specific antigens can be induced by demethylation drugs. Antigen-targeting DC-CTL cells supposed to eliminate cancer cells efficiently and specifically. In this study investigators co-culture DCs cells with peptides derived from tumor specific antigen to generate antigen-specific DC-CTLs (Ag-CTL). Following treatment with demethylation drugs, Ag-CTL will be used to eliminate tumor …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Camrelizumab Plus Decitabine in Anti-PD-1 Treatment-naive Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

This is an open-label, Phase 2/3multicenter and single-arm clinical trial of Camrelizumab plus decitabine for Anti-PD-1 treatment-naive patients with relapsed or refractory Hodgkin Lymphoma. The

cell transplantation
refractory classical hodgkin lymphoma
classical hodgkin lymphoma
refractory hodgkin lymphoma
lymphoma
  • 0 views
  • 24 Jan, 2021
  • 1 location
Metabolically Optimized, Non-cytotoxic Low Dose Weekly Decitabine/Venetoclax in MDS and AML

these cells and causes their death. Unfortunately, such therapy has side-effects, since even normal cells can be affected by the treatment. Decitabine is FDA approved for treatment of MDS and AML

  • 0 views
  • 27 Apr, 2022
  • 1 location
Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast Ca

This study is a 2-cohort, open-label, multicenter, phase 2 study of a short course of immunotherapy consisting of sequential decitabine followed by pembrolizumab administered prior to a standard

carboplatin
cancer
decitabine
oophorectomy
advanced breast cancer
  • 64 views
  • 29 Apr, 2022
  • 5 locations
Study of Pembrolizumab Combined With Decitabine and Pralatrexate in PTCL and CTCL

), recommended phase 2 dose (RP2D), dose limiting toxicities (DLTs) and to evaluate the clinical efficacy at the MTD of various combinations of pembrolizumab, pralatrexate and decitabine.

fungal infection
decitabine
t-cell lymphoma
lymphoma
mycosis
  • 81 views
  • 12 May, 2022
  • 1 location
tailOred dRug repurposIng of dEcitabine in KRAS-dependeNt refracTory pAncreaTic cancEr (ORIENTATE)

The study is designed to assess the therapeutic efficacy of decitabine repurposing against advanced, refractory, ductal adenocarcinoma (PDAC) with molecular transcriptional signatures indicating

  • 0 views
  • 11 May, 2022
  • 1 location
Study of Venetoclax in Combination With Decitabine in Subjects With Acute Myeloid Leukemia

The main purpose of this study is to learn about the safety and tolerability of an experimental drug, Venetoclax, when it is given along with Decitabine in subjects diagnosed with acute myeloid

decitabine
venetoclax
  • 0 views
  • 30 May, 2022
  • 1 location
Decitabine and HQP1351-based Chemotherapy Regimen for the Treatment Advanced CML (Case-Only)

This phase II trial studies how well the combination of based decitabine and olverembatinib(HQP1351)chemotherapy work for the treatment of blast phase or accelerated phase chronic myelogenous

  • 0 views
  • 27 May, 2022
  • 1 location
Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ipilimumab when given together with decitabine in treating patients with myelodysplastic syndrome or acute myeloid leukemia that has

cancer
ipilimumab
refractory acute myeloid leukemia (aml)
myelodysplastic syndromes
decitabine
  • 235 views
  • 16 Jun, 2022
  • 3 locations
Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial (DART)

patients) to assess efficacy of decitabine in the treatment of critically ill patients with COVID-ARDS. The patients will be randomized in a 1:1 ratio to receive standard of care plus Decitabine or

mechanical ventilation
critical illness
acute respiratory distress
PCR test
coronavirus infection
  • 69 views
  • 20 Jun, 2022
  • 1 location