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Found 16 clinical trials
Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery (FLORA-5)

Study to compare the safety and efficacy of oregovomab versus placebo, administered in combination with specific cycles of a standard six-cycle chemotherapy regimen (paclitaxel and carboplatin), for the treatment of subjects with newly diagnosed advanced ovarian cancer who have undergone optimal debulking.

endometrioid adenocarcinoma
carcinoma
interval debulking surgery
chemotherapy regimen
renal function
  • 149 views
  • 24 Jul, 2022
  • 76 locations
Efficacy of Primary Debulking Surgery Versus Neoadjuvant Chemotherapy in Stage IV Ovarian Cancer

Epithelial ovarian cancer is mostly diagnosed at late stage (III/IV), and the standard treatment for ovarian cancer includes primary debulking surgery and platinum-based adjuvant chemotherapy

ovarian epithelial carcinoma
tumor debulking
cancer chemotherapy
stage iv ovarian cancer
primary debulking surgery
  • 0 views
  • 27 May, 2022
  • 1 location
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer (CHIPPI) (CHIPPI)

This is a phase III, multicenter, interventional and randomized study which evaluates the use of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) coupled with either Primary Debulking Surgery

carcinoma
interval debulking surgery
intraperitoneal chemotherapy
renal function
adenocarcinoma
  • 3 views
  • 07 Feb, 2022
  • 6 locations
Using Aspirin to Improve Immunological Features of Ovarian Tumors

The purpose of the study is to evaluate the effectiveness of aspirin with neoadjuvant chemotherapy for decreasing markers of immune suppression in the tumor at interval debulking surgery, in

ct scan
carcinoma
interval debulking surgery
tumor debulking
fallopian tube
  • 0 views
  • 23 Dec, 2021
  • 1 location
A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)

, during, and after primary debulking surgery/PDS and also if it's better than the standard-of-care approach (no intervention for reducing stress).

laparotomy
carcinoma
tumor debulking
fallopian tube
ovarian cancer
  • 0 views
  • 13 Jul, 2022
  • 7 locations
Niraparib Maintenance in Patients With Advanced Ovarian Cancer at Neoadjuvant Setting

This study aims to evaluate the effects of niraparib in those who have received neoadjuvant chemotherapy and subsequent interval debulking surgery, with or without hyperthermic intraperitoneal

cytoreductive surgery
carcinoma
parp inhibitor
interval debulking surgery
tumor debulking
  • 0 views
  • 06 Oct, 2021
  • 1 location
Efficacy of Neoadjuvant Therapy With Cisplatin Plus Mitomycin C in BRCA1-Mutated Ovarian Cancer

This study was designed to assess the safety and efficacy of neoadjuvant therapy with mitomycin C plus cisplatin (MP) in BRCA1-mutated ovarian cancer versus standard regimen (paclitaxel plus carboplatin (TP)).

  • 0 views
  • 18 Feb, 2021
  • 1 location
Prehabilitation in Gynaecological Cancer Patients (PHOCUS)

Prehabilitation refers to interventions aiming to improve patients' resilience and functional capacity before a known stressful event, e.g., scheduled surgery. These interventions usually consist of physical activity and psychological and nutritional support. There is substantial evidence of the positive effect of multimodal prehabilitation among patients treated surgically for non-gynaecological cancers; …

ovarian epithelial carcinoma
interval debulking surgery
tumor debulking
cancer
ovarian cancer
  • 0 views
  • 20 Apr, 2022
  • 1 location
Prehabilitation for Advanced Ovarian Cancer Patients

Physical activity plays an important role in reducing the adverse effects of cancer treatment. There are few studies using prehabilitation to improve peri-operative outcomes in patients undergoing cancer surgery. This study will pilot a program of structured activity for women undergoing neoadjuvant chemotherapy with the intent to improve their physical …

cancer of the ovary
fallopian tube
peritoneal cancer
platinum-based chemotherapy
cancer chemotherapy
  • 0 views
  • 28 Jul, 2022
  • 1 location
IMPACT: A Randomized WOO Study of Novel Therapeutic Agents in Women Triaged to Primary Surgery for EOC (IMPACT)

The study will be conducted in women with advanced (stage IIIa-IV) ovarian cancer of the histologic subtype high grade serous carcinoma (HGSOC) who are going through a diagnostic laparoscopy. They will recieve treatment with a study agent for 10-14 days before surgery. They will be allocated to different study groups …

cytoreductive surgery
carcinoma
cancer of the ovary
serous cystadenocarcinoma
peritoneal cancer
  • 2 views
  • 27 Feb, 2022
  • 2 locations