Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 69 clinical trials
Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more …

asparaginase
mercaptopurine
combination chemotherapy
thioguanine
cyclophosphamide
  • 1 views
  • 07 Nov, 2020
  • 5 locations
Acute Promyelocytic Leukemia 2006 (APL)

To assess the role of Arsenic trioxide and/or ATRA during consolidation course in APL. It is hoped that the investigational arms will further increase the event-free survival at 2 years, with reduced toxicity and without increasing the relapse rate by comparison with a classical anthracycline-AraC consolidation regimen.

tretinoin
anthracyclines
arsenic
idarubicin
  • 13 views
  • 07 Nov, 2020
  • 1 location
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. A donor stem cell transplant may replace the patient's immune cells …

asparaginase
etoposide
prednisone
graft-versus-tumor
combination chemotherapy
  • 0 views
  • 07 Nov, 2020
  • 1 location
AIDA2000 - Risk-Adapted Therapy for Patients With Acute Promyelocytic Leukemia

with ATRA and idarubicin followed by postremission therapy with daunorubicin and mitoxantrone in age adapted dosages. Patients with an high WBC were additionally treated with cytarabine

methotrexate
retinoids
consolidation therapy
tretinoin
induction therapy
  • 40 views
  • 07 Nov, 2020
  • 1 location
Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE

20-25% of patients over 15 years with acute lymphoblastic leukemia (ALL) have the Philadelphia chromosome or BCR-ABL rearrangement. Traditionally, intensive chemotherapy followed by hematopoietic stem cell transplantation (HSCT) have formed the basis allogeneic treatment of this disease, but the results have been poor (60-75% complete remissions-RC-and probability of long-term survival …

  • 103 views
  • 03 Feb, 2021
  • 112 locations
Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

This phase II/III trial studies how well daunorubicin and cytarabine with or without uproleselan works in treating older adult patients with acute myeloid leukemia receiving intensive induction

leukapheresis
methotrexate
lenalidomide
acute promyelocytic leukemia
hydroxyurea
  • 25 views
  • 24 Feb, 2021
  • 98 locations
Comparison Between Two Dose Levels of Daunorubicin and Between One vs. Two Induction Cycles for Adult Patients With AML

The proposed trial will address two clinically important questions for younger patients with newly diagnosed acute myeloid leukemia (AML): the optimal dose of daunorubicin in induction therapy

ejection fraction
minimal residual disease
neoadjuvant therapy
daunorubicin
residual tumor
  • 33 views
  • 24 Jan, 2021
  • 41 locations
A Study of Midostaurin Efficacy and Safety in Newly Diagnosed Patients With FLT3-mutated AML

This study will evaluate the efficacy and safety of midostaurin in combination with daunorubicin/cytarabine induction, high dose cytarabine consolidation and midostaurin single agent

gilbert's syndrome
cytarabine
daunorubicin
cytarabine/daunorubicin
acute promyelocytic leukemia
  • 46 views
  • 22 Feb, 2021
  • 49 locations
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia

with cytarabine plus mitoxantrone or liposomal daunorubicin in induction To compare mitoxantrone (anthracenedione) & cytarabine with liposomal daunorubicin (anthracycline) &amp

myeloablative conditioning
neoadjuvant therapy
gemtuzumab
remission
fludarabine
  • 0 views
  • 26 Jan, 2021
  • 59 locations
Study to Improve OS in 18 to 60 Year-old Patients Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR

This open label, multicenter phase II/III study with multiple randomization phases at differents stages of AML treatment (induction, consolidation and HSCT where applicable) is designed to improve OS in younger (18 to 60 year-old) patients, with AML risk-adapted patient strategies. Within the intermediate risk AML group, optimal GvHD prophylaxis following …

venetoclax
vosaroxin
colony stimulating factor
blast cells
granulocyte colony stimulating factor
  • 42 views
  • 25 Jan, 2021
  • 57 locations