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Found 11 clinical trials
Featured trial
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …

sickle cell disease
stroke
cell transplantation
red blood cell disorder
  • 83 views
  • 22 Dec, 2020
  • 1 location
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

>Patients with membranous nephropathy are often treated with immunosuppressive drugs such as cyclosporine or cytoxan plus steroids that attempt to reduce or suppress the activity of the immune system

cyclosporin
blood tests
blood test
angiotensin ii receptor antagonists
intravenous infusions
  • 243 views
  • 28 Jun, 2022
  • 2 locations
High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) affects white blood cell function. Currently, the only curative treatment is bone marrow transplant to replace the abnormal stem cells with new ones (donor cells) capable of making a normal immune system. Transplant problems include graft versus host disease (GvHD) and graft rejection. With GvHD, donor …

  • 3 views
  • 18 Apr, 2022
  • 1 location
Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL) (MABEL)

The subject has a type of cancer or lymph gland disease associated with a virus called Epstein Barr Virus (EBV), which has come back, is at risk of coming back, or has not gone away after standard treatments. This research study uses special immune system cells called LMP, BARF-1 and …

hodgkin's disease
cyclophosphamide
solid tumour
immunosuppressive
pulse oximetry
  • 11 views
  • 24 Mar, 2022
  • 2 locations
Activated T Lymphocytes Expressing CARs, Relapsed CD19+ Malignancies Post-Allo HSCT(CARPASCIO) (CARPASCIO)

Patients have a type of lymph gland cancer called Non-Hodgkin Lymphoma (NHL), acute lymphocytic leukemia (ALL) or chronic lymphocytic leukemia (CLL) (these diseases will be referred to as "lymphoma" or "leukemia"). The lymphoma or leukemia has come back or has not gone away after treatment (including the best treatment known …

chronic lymphocytic leukemia
hodgkin's disease
immunoglobulin
flow cytometry
tumor cells
  • 69 views
  • 24 Mar, 2022
  • 2 locations
Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN) (SAGAN)

Subjects on this study have a type of lymph gland cancer called Non-Hodgkin Lymphoma, acute lymphocytic leukemia, or chronic Lymphocytic Leukemia (these diseases will be referred to as "lymphoma" or "leukemia"). The lymphoma or leukemia has come back or has not gone away after treatment. The body has different ways …

chronic lymphocytic leukemia
hodgkin's disease
cyclophosphamide
lymphoma
oximetry
  • 69 views
  • 21 Mar, 2022
  • 2 locations
A Personalized Neoantigen Cancer Vaccine in Treatment Na ve Asymptomatic Patients With IGHV Unmutated CLL.

This research study is studying a novel type of CLL vaccine as a possible treatment for chronic lymphocytic leukemia (CLL) The names of the study interventions involved in this study are: Personalized NeoAntigen Vaccine Poly-ICLC Cyclophosphamide Pembrolizumab

  • 0 views
  • 28 Sep, 2021
  • 1 location
Hematopoietic Stem Cell Transplant for Sickle Cell Disease

This is a phase I/II study of patients with sickle cell disease. It aims to find out if people with sickle cell disease can be cured by changing their immune system before they have blood stem cell transplants. Doctors will give patients a new drug (fludarabine) to see if this …

stroke
sickle hemoglobin
anti-thymocyte globulin
acute chest syndrome
hemoglobin c disease
  • 84 views
  • 14 Jun, 2022
  • 1 location
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective To see if a new transplant regime is effective, safe and well …

sirolimus
cyclophosphamide
Accepts healthy volunteers
blood test
x-rays
  • 2 views
  • 02 Jul, 2022
  • 1 location
Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Hepatocellular Carcinoma

Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment. This research study uses special immune system cells called CATCH T cells, a new experimental treatment. The body has different ways of fighting infection and disease. …

  • 0 views
  • 21 Mar, 2022
  • 1 location