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Found 34 clinical trials
Protein Phosphatase 2A Inhibitor in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

recurrent glioblastoma
glioblastoma multiforme
platelet count
recurrent disease
renal function test
  • 12 Sep, 2021
  • 1 location
PLX3397 in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN)

Background Some people with cancer have solid tumors. Others have refractory leukemia. This doesn t go away after treatment. Researchers want to see if a drug called PLX3397 can shrink tumors or stop them from growing. Objectives To find the highest safe dose and side effects of PLX3397. To see …

solid tumour
measurable disease
graft versus host disease
cancer chemotherapy
ejection fraction
  • 12 Sep, 2021
  • 1 location
First-Line EGFR-1 Tyrosine Kinase Inhibition in Patients With NSCLC With Mutant EGFR Gene

Current chemotherapy for advanced non-small cell lung cancer, not amenable for curative local treatment (surgery or chemoradiotherapy), has a modest life-prolonging effect and can improve quality of life. There is however no potential for long-term cure for these patients. Chemotherapy also produces variable and often significant toxicity. Current retrospective evidence …

measurable disease
adjuvant chemotherapy
granulocyte count
kidney function test
  • 07 Nov, 2020
  • 1 location
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)

This is a non-interventional observational study aimed at understanding the real world effectiveness of novel agents used in treating multiple myeloma and their impact on patient-reported outcomes. This study will collect information that is already in medical records regarding treatment and diagnostic procedures. Patients are asked to complete questionnaires for …

immunomodulatory imide drug
proteasome inhibitor
line of therapy
  • 22 Jan, 2021
  • 76 locations