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Found 34 clinical trials
Hyperpolarized Carbon-13 Imaging of Metastatic Prostate Cancer

A pilot study with a group of up to 10 men with CRPC about to embark on a 6-month course of treatment with radium 223. Study participants will undergo anatomical MR imaging combined with the new hyperpolarized MRI (1 hour exam) prior to treatment.

neutrophil count
platelet count
metastatic prostate cancer
castration-resistant prostate cancer
prostate cancer metastatic
  • 08 Apr, 2021
  • 1 location
Radiotherapy of Multiple Brain Metastases Using AGuIX

This is a Prospective Randomized Open Blinded Endpoint phase II clinical trial. The study will be adaptive: an interim analysis is planned after enrolment of 20 patients in each arm of treatment (WBRT and AGuIX + WBRT), to select and continue the study with group(s) that present the best response …

brain metastases
whole brain radiation therapy
solid tumor
  • 10 Mar, 2021
  • 13 locations
Peri-operative Association of Immunotherapy (Pre-operative Association of Nivolumab and Ipilimumab Post-operative Nivolumab Alone) in Localized Microsatellite Instability (MSI) and/or Deficient Mismatch Repair (dMMR) Oeso-gastric Adenocarcinoma

This is a non-randomized study, open label phase II study. The purpose of this study is to evaluate the complete pathologic response rate (cPRR) with neoadjuvant nivolumab and ipilimumab combination in patients with MSI and/or dMMR localized oeso-gastric cancer.

  • 20 Jun, 2021
  • 15 locations
Fludarabine in Combination With Daunorubicin and Cytarabine Liposome in Newly-diagnosed Acute Myeloid Leukemia.

This phase 2 clinical trial will evaluate the effectiveness and safety of fludarabine in combination with CPX-351 in patients with untreated AML. Patients will receive fludarabine and CPX-351 during Induction 1 and 2 as well as 2 cycles of consolidation therapy.

  • 08 Apr, 2021
  • 1 location
Intratumoral Cisplatin for Resectable NSCLC

PRIMARY OBJECTIVE: To identify the maximum tolerated dose (MTD) of intratumoral cisplatin, delivered during a single bronchoscopy with cone-beam CT confirmation, in a dose escalation protocol DESIGN: 3+3 dose escalation.

  • 29 Mar, 2021
  • 1 location
Effect of Hemp-CBD on Patients With CIPN

The purpose of this study is to assess the effect of a hemp-based cannabidiol (CBD) product, Ananda Hemp Spectrum Gelcaps, on the severity and duration of chemotherapy-induced neuropathy (CIPN) among non-metastatic breast, colorectal, uterine and ovarian cancer patients who received neoadjuvant or adjuvant therapy that included neurotoxic chemotherapeutic agents.

stage iv breast cancer
cancer of the ovary
  • 25 Jan, 2021
  • 1 location
Phase I/II Study of Hydroxychloroquine With Itraconazole With Biochemically Recurrent Prostate Cancer

Recent pre-clinical work has suggested that Itraconazole has an anti-cancer effect that works synergistically with hydroxychloroquine. This may delay the need for androgen deprivation therapy (ADT) and its associated toxicities in men with biochemically recurrent (BCR) prostate cancer. This study aims to determine feasibility, safety and efficacy of suba-itraconazole (SI) …

antiandrogen therapy
androgen suppression
  • 11 Mar, 2021
  • 1 location
Sodium Selenite as a Cytotoxic Agent in Advanced Carcinoma

In vitro studies have demonstrated that sodium selenite in sufficient concentration and during sufficient time have a high tumoricidal capacity. This is found in many human cell types as leukemia cells, mesothelioma and non-small cell lung cancer cells. A minority of cell lines seem to be resistant. The question from …

lung cancer
treatment regimen
primary cancer
  • 08 Nov, 2020
  • 1 location
Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma

Background The disease follicular lymphoma (FL) develops when the body makes abnormal B-cells. These cells usually build up in the lymph nodes, but can also affect other parts of the body. Researchers want to see if a combination of drugs can attack the cancer cells in people with FL. Objective …

neutrophil count
gilbert's syndrome
antibody therapy
  • 18 Sep, 2021
  • 1 location
Efficacy and Safety of Dose-dense Chemotherapy (ddEC-ddP) for Neoadjuvant Chemotherapy of HER2-negative Breast Cancer

Recent clinical studies showed that breast cancer patients especially for those with lymph node metastasis may benefit from dose-dense chemotherapy, like adriamycin and cyclophosphamide (AC) q2w4 paclitaxel (P) q2w4. However, the studies on dose-dense (dd) regimen chemotherapy is mostly based on postoperative adjuvant chemotherapy and the optimum of dose-dense chemotherapy …

  • 20 Aug, 2021
  • 1 location