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Found 13 clinical trials
Physical Training in Glioblastoma Patients During Cytotoxic Therapy

adjuvant cytotoxic therapy. The research question is whether physical exercise is feasible and whether patients benefit physically and mentally from the activities performed. For this purpose, specific

cytotoxic chemotherapy
  • 0 views
  • 29 Aug, 2021
  • 1 location
Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells

transfer in adult and pediatric participants suffering from CMV infections or reactivation following HSCT or due to other immunocompromised states (e.g.; primary immunodeficiency, cytotoxic therapy).

antiviral drugs
colitis
viremia
dhpg
pneumonia
  • 41 views
  • 08 Feb, 2022
  • 1 location
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc) (Stereosarc)

Up to 50% of soft tissue sarcoma (STS) patients will develop metastases in the course of their disease. Cytotoxic therapy is a standard treatment in this setting but yields average tumor

cancer chemotherapy
leiomyosarcoma
neutrophil count
metastasis
ipilimumab
  • 0 views
  • 10 Aug, 2022
  • 1 location
Neo-adjuvant Pembrolizumab in Primary Stage IV Ovarian Cancer

This is a single arm feasibility study in patients with primary FIGO stage IV serous ovarian, peritoneal, or fallopian tube cancer to evaluate neo-adjuvant + adjuvant pembrolizumab for its capacity to induce and broaden T cell responses against tumor neo-antigens.

pembrolizumab
immunological adjuvant
fallopian tube
cancer of the ovary
immunostimulant
  • 222 views
  • 07 Apr, 2022
  • 1 location
Efficacy of Neoadjuvant Therapy With Cisplatin Plus Mitomycin C in BRCA1-Mutated Ovarian Cancer

This study was designed to assess the safety and efficacy of neoadjuvant therapy with mitomycin C plus cisplatin (MP) in BRCA1-mutated ovarian cancer versus standard regimen (paclitaxel plus carboplatin (TP)).

  • 0 views
  • 18 Feb, 2021
  • 1 location
Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

Background Less toxic and more effective treatments are needed for cancers caused by viruses. These cancers include Hodgkin and non-Hodgkin lymphoma, hepatocellular carcinoma, head and neck cancer, nasopharyngeal carcinoma, gastric cancer, anal cancer, cervical cancer, vaginal cancer, vulvar cancer, penile cancer, Merkel cell carcinoma, Kaposi sarcoma, and leiomyosarcoma. Researchers want …

etoposide
combination chemotherapy
aspirin
monoclonal antibodies
cancer
  • 0 views
  • 21 Jul, 2022
  • 1 location
Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma

Background Kaposi Sarcoma (KS) is common in people with human immunodeficiency virus (HIV) but can also occur in people who do not have HIV. KS tumors usually involve the skin, but may also involve lymph nodes, lungs, bone, and gastrointestinal tract. Researchers want to see if a drug that is …

progressive disease
measurable disease
immunodeficiency
atazanavir
cancer
  • 0 views
  • 25 Jul, 2022
  • 1 location
NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Background Kaposi sarcoma (KS) tumors grow on the skin, lymph nodes, lungs, bone, and gastrointestinal tract. KS often affects people with immune deficiencies, such as among people living with HIV or those with prior history of transplant. Researchers want to see if 2 non-chemotherapy drugs can help people with KS. …

progressive disease
measurable disease
atazanavir
monoclonal antibodies
systemic chemotherapy
  • 12 views
  • 22 Jul, 2022
  • 1 location
Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma

Background Kaposi sarcoma (KS) is a cancer most often seen in people with HIV. It causes lesions. These are usually on the skin but sometimes in the lymph nodes, lungs, and gastrointestinal tract. Researchers think a combination of drugs may help treat KS. Objective To test a combination of the …

aspirin
cancer
neutrophil count
cytotoxic chemotherapy
antiretroviral therapy
  • 11 views
  • 25 Jul, 2022
  • 1 location
Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) (ABC-X)

This is a phase II, open label, randomised trial of ipilimumab and nivolumab with concurrent intracranial stereotactic radiotherapy versus ipilimumab and nivolumab alone in patients with asymptomatic, untreated melanoma brain metastases.

  • 16 views
  • 26 Jul, 2022
  • 5 locations