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Found 13 clinical trials
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy

RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and …

hysterectomy
tumor cells
cancer
cervical cancer stage
pelvic radiation
  • 255 views
  • 23 Jan, 2021
  • 4 locations
Physical Training in Glioblastoma Patients During Cytotoxic Therapy

adjuvant cytotoxic therapy. The research question is whether physical exercise is feasible and whether patients benefit physically and mentally from the activities performed. For this purpose, specific

cytotoxic chemotherapy
  • 0 views
  • 29 Aug, 2021
  • 1 location
Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells

transfer in adult and pediatric participants suffering from CMV infections or reactivation following HSCT or due to other immunocompromised states (e.g.; primary immunodeficiency, cytotoxic therapy).

viremia
ganciclovir
antiviral drugs
antiviral therapy
valganciclovir
  • 41 views
  • 29 Jan, 2021
  • 1 location
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc)

Up to 50% of soft tissue sarcoma (STS) patients will develop metastases in the course of their disease. Cytotoxic therapy is a standard treatment in this setting but yields average tumor

tumor cells
cancer chemotherapy
soft tissue sarcoma
neutrophil count
metastasis
  • 0 views
  • 09 Jul, 2021
  • 11 locations
Neo-adjuvant Pembrolizumab in Primary Stage IV Ovarian Cancer

This is a single arm feasibility study in patients with primary FIGO stage IV serous ovarian, peritoneal, or fallopian tube cancer to evaluate neo-adjuvant + adjuvant pembrolizumab for its capacity to induce and broaden T cell responses against tumor neo-antigens.

pembrolizumab
immunostimulant
immunological adjuvant
ovarian cancer
cancer
  • 206 views
  • 29 Jan, 2021
  • 1 location
Efficacy of Neoadjuvant Therapy With Cisplatin Plus Mitomycin C in BRCA1-Mutated Ovarian Cancer

This study was designed to assess the safety and efficacy of neoadjuvant therapy with mitomycin C plus cisplatin (MP) in BRCA1-mutated ovarian cancer versus standard regimen (paclitaxel plus carboplatin (TP)).

  • 0 views
  • 18 Feb, 2021
  • 1 location
Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

Background Less toxic and more effective treatments are needed for cancers caused by viruses. These cancers include Hodgkin and non-Hodgkin lymphoma, hepatocellular carcinoma, head and neck cancer, nasopharyngeal carcinoma, gastric cancer, anal cancer, cervical cancer, vaginal cancer, vulvar cancer, penile cancer, Merkel cell carcinoma, Kaposi sarcoma, and leiomyosarcoma. Researchers want …

anthracyclines
cancer chemotherapy
antiretroviral therapy
ct scan
cancer
  • 0 views
  • 19 Sep, 2021
  • 1 location
NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Background Kaposi sarcoma (KS) tumors grow on the skin, lymph nodes, lungs, bone, and gastrointestinal tract. KS often affects people with immune deficiencies, such as among people living with HIV or those with prior history of transplant. Researchers want to see if 2 non-chemotherapy drugs can help people with KS. …

doxorubicin
monoclonal antibodies
cancer chemotherapy
cancer
systemic therapy
  • 12 views
  • 12 Sep, 2021
  • 1 location
Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma

Background Kaposi Sarcoma (KS) is common in people with human immunodeficiency virus (HIV) but can also occur in people who do not have HIV. KS tumors usually involve the skin, but may also involve lymph nodes, lungs, bone, and gastrointestinal tract. Researchers want to see if a drug that is …

cancer
systemic therapy
breast cancer
protease
neutrophil count
  • 0 views
  • 19 Sep, 2021
  • 1 location
Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma

Background Kaposi sarcoma (KS) is a cancer most often seen in people with HIV. It causes lesions. These are usually on the skin but sometimes in the lymph nodes, lungs, and gastrointestinal tract. Researchers think a combination of drugs may help treat KS. Objective To test a combination of the …

antiretroviral therapy
ct scan
systemic therapy
cancer
cancer chemotherapy
  • 11 views
  • 12 Sep, 2021
  • 1 location