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Found 12 clinical trials
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy

RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and …

hysterectomy
carboplatin
paclitaxel
cancer
carcinoma
  • 255 views
  • 23 Jan, 2021
  • 4 locations
Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells

transfer in adult and pediatric participants suffering from CMV infections or reactivation following HSCT or due to other immunocompromised states (e.g.; primary immunodeficiency, cytotoxic therapy).

stem cell transplantation
foscarnet
valganciclovir
antiviral drugs
dhpg
  • 41 views
  • 29 Jan, 2021
  • 1 location
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc)

Up to 50% of soft tissue sarcoma (STS) patients will develop metastases in the course of their disease. Cytotoxic therapy is a standard treatment in this setting but yields average tumor

immunomodulators
cancer chemotherapy
soft tissue sarcoma
liposarcoma
neutrophil count
  • 0 views
  • 24 Jan, 2021
  • 10 locations
Neo-adjuvant Pembrolizumab in Primary Stage IV Ovarian Cancer

This is a single arm feasibility study in patients with primary FIGO stage IV serous ovarian, peritoneal, or fallopian tube cancer to evaluate neo-adjuvant + adjuvant pembrolizumab for its capacity to induce and broaden T cell responses against tumor neo-antigens.

fallopian tube
carboplatin
immunological adjuvant
paclitaxel
ovarian cancer
  • 206 views
  • 29 Jan, 2021
  • 1 location
Study of Pembrolizumab in Locally Advanced Esophageal Adenocarcinoma

This is a randomized, multicenter phase II study of pembrolizumab in combination with chemotherapy and chemoradiation in locally advanced esophageal adenocarcinoma to examine the safety and efficacy of the combination of pembrolizumab with chemotherapy and chemoradiation in locally advanced esophageal adenocarcinoma as assessed by 1 year disease free survival rate.

carboplatin
anticoagulants
direct bilirubin
pembrolizumab
neutrophil count
  • 0 views
  • 28 Jan, 2021
  • 4 locations
Efficacy of Neoadjuvant Therapy With Cisplatin Plus Mitomycin C in BRCA1-Mutated Ovarian Cancer

This study was designed to assess the safety and efficacy of neoadjuvant therapy with mitomycin C plus cisplatin (MP) in BRCA1-mutated ovarian cancer versus standard regimen (paclitaxel plus carboplatin (TP)).

  • 0 views
  • 18 Feb, 2021
  • 1 location
History of the KSHV Inflammatory Cytokine Syndrome (KICS)

Background KSHV inflammatory cytokine syndrome (KICS) is a newly recognized disease caused by Kaposi sarcoma-associated herpesvirus (KSHV). This virus can cause cancer. People with KICS can have severe symptoms. They include fever, weight loss, and fluid in the legs or abdomen. People with KICS may also be at risk of …

herpes
doxorubicin
lymphoma
fever
imaging procedure
  • 81 views
  • 26 Jan, 2021
  • 1 location
NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Background Kaposi sarcoma (KS) tumors grow on the skin, lymph nodes, lungs, bone, and gastrointestinal tract. KS often affects people with immune deficiencies, such as among people living with HIV or those with prior history of transplant. Researchers want to see if 2 non-chemotherapy drugs can help people with KS. …

lung exam
progressive disease
measurable disease
cancer chemotherapy
doxorubicin
  • 12 views
  • 05 May, 2021
  • 1 location
Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma

Background Kaposi sarcoma (KS) is a cancer most often seen in people with HIV. It causes lesions. These are usually on the skin but sometimes in the lymph nodes, lungs, and gastrointestinal tract. Researchers think a combination of drugs may help treat KS. Objective To test a combination of the …

measurable disease
cancer chemotherapy
ct scan
protease
neutrophil count
  • 11 views
  • 01 Mar, 2021
  • 1 location
Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study)

This is a phase II, open label, randomised trial of ipilimumab and nivolumab with concurrent intracranial stereotactic radiotherapy versus ipilimumab and nivolumab alone in patients with asymptomatic, untreated melanoma brain metastases.

  • 16 views
  • 26 Jan, 2021
  • 6 locations