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Found 23 clinical trials
Open-label Dose Escalation Phase 1b Trial of a New Micellar Docetaxel Compound in Patients With mCRPC

Treatment with polysorbate 80-solved Docetaxel (Taxotere®) is hampered by the requirement to co-administer steroids. Chronic (intermittent) steroids are negatively impacting bone health and have well known immunosuppressive effects. Despite steroid premedication, polysorbate 80-solved Docetaxel (Taxotere®) results in occasional infusion reactions due to the solvent polysorbate 80. Docetaxel micellar is a …

  • 0 views
  • 07 Jan, 2022
  • 3 locations
The Role of Ruxolitinib in Secondary Acute Myelogenous Leukemia Evolving From Myeloproliferative Neoplasm

This trial aimed to investigate the therapeutic efficacy of ruxolitinib in combination with cytotoxic chemotherapy for post-myeloproliferative neoplasm secondary acute myeloid leukemia.

  • 1 views
  • 04 Mar, 2022
  • 2 locations
Proof of Principle Study Evaluating Gonyautoxins NEURO SERUM, on Chemotherapy-induced Peripheral Neuropathy

Proof-of-concept study to assess the effects of gonyautoxins (PSP NEURO SERUM) on safety and tactile sensitivity on patients with chemotherapy-induced peripheral neuropathy (CIPN). This is a multicenter, prospective proof-of-concept study in patients with solid tumors affected by CIPN. The study will be divided into two parts: Part 1 will assess …

  • 0 views
  • 24 Mar, 2022
  • 5 locations
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer (SASCIA)

cytotoxic agents.

BRCA1/2
carboplatin
mastectomy
erbb2
carcinoma
  • 10 views
  • 28 Apr, 2022
  • 69 locations
International Study for Treatment of High Risk Childhood Relapsed ALL 2010

The main goal of this study is to improve the outcome of children and adolescents with acute lymphoblastic leukemia with high risk first relapse by optimization of treatment strategies within a large international trial and the integration of new agents.

  • 34 views
  • 05 Mar, 2022
  • 10 locations
9-ING-41 in Patients With Advanced Cancers

inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.

primary cancer
carboplatin
absolute neutrophil count
solid neoplasm
solid tumors
  • 795 views
  • 29 May, 2022
  • 10 locations
Patients With ES-SCLC and ECOG PS=2 Receiving Atezolizumab-Carboplatin-Etoposide (SPACE)

SCLC patients develop brain metastases. New cytotoxic agents as well as targeted therapies have not been able to show any improvement of survival in this group of patients. Early phase

carboplatin
metastasis
aptt
neutrophil count
atezolizumab
  • 0 views
  • 23 Feb, 2022
  • 5 locations
Dose Individualization of Pemetrexed - IMPROVE-I (IMPROVE-I)

mesothelioma. Dosing of cytotoxic agents like pemetrexed requires balancing the dual risk of sub-therapy and toxicity. Administration of pemetrexed to patients with a creatinine clearance <45 ml/min is

kidney function test
renal function
folic acid
cytotoxic agents
folate antagonist
  • 4 views
  • 07 Oct, 2022
  • 3 locations
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc) (Stereosarc)

immunomodulatory agents appear to be synergistic and show favorable tolerance profiles. Immunomodulatory agents have a more favorable toxicity profile than cytotoxic agents with about 65% overall acute toxicities

tumor cells
liposarcoma
neutrophil count
immunomodulators
leiomyosarcoma
  • 0 views
  • 04 Oct, 2022
  • 1 location
Peri-operative Association of Immunotherapy (Pre-operative Association of Nivolumab and Ipilimumab Post-operative Nivolumab Alone) in Localized Microsatellite Instability (MSI) and/or Deficient Mismatch Repair (dMMR) Oeso-gastric Adenocarcinoma

This is a non-randomized study, open label phase II study. The purpose of this study is to evaluate the complete pathologic response rate (cPRR) with neoadjuvant nivolumab and ipilimumab combination in patients with MSI and/or dMMR localized oeso-gastric cancer.

  • 0 views
  • 20 Jun, 2021
  • 15 locations