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Found 40 clinical trials
Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) Haploinsufficiency

inflamed brain and nerve problems. Many have problems with their bone marrow causing low numbers of blood cells like platelets, red blood cells or white blood cells, which is called cytopenia. Researchers

  • 2 views
  • 15 Jun, 2022
  • 1 location
Repurposing Metformin as a Leukemia-preventive Drug in CCUS and LR-MDS

This is a phase 2 single-arm pilot study of the efficacy and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic syndrome (MDS

cytopenia
leukemia
Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 1 location
A Study of KER-050 to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes

The purpose of this study is to evaluate the effects of KER-050 on anemia in patients with very low, low or intermediate risk MDS.

anemia
blood transfusion
bone marrow procedure
  • 72 views
  • 05 May, 2022
  • 12 locations
  • 0 views
  • 16 Apr, 2021
  • 1 location
Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies (EVITA)

; i.e., clonal cytopenia of undetermined significance (CCUS), low-risk myelodysplastic syndromes (MDS), and chronic myelomonocytic leukemia (CMML)-0/1 by reversing the epigenetic changes characteristic

myelomonocytic leukemia
bone marrow procedure
cytopenia
leukemia
chronic myelomonocytic leukemia
  • 52 views
  • 14 Feb, 2022
  • 4 locations
TPM Regimen (Thalidomide Prednisone and Methotrexate) in LGLL

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disease, with LGL infiltration in peripheral blood and bone marrow, hepatosplenomegaly, and cytopenia. Both T-LGLL and CLPD-NK

lymphoid leukemia
  • 0 views
  • 24 Jan, 2021
  • 9 locations
Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

This clinical trial studies the use of reduced intensity chemotherapy and radiation therapy before donor stem cell transplant in treating patients with hematologic malignancies. Giving low doses of chemotherapy, such as cyclophosphamide and fludarabine phosphate, before a donor stem cell transplant may help stop the growth of cancer cells. It …

myeloid leukemia
myeloproliferative disorder
blast cells
myelodysplastic syndrome with excess blasts-2
carbon monoxide
  • 66 views
  • 20 Apr, 2022
  • 1 location
Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenstr m Macroglobulinemia

disorder requires treatment only in case of symptoms, according to accurate criteria described during the second Workshop on WM i.e. in case of cytopenia, bulky organomegaly, immunological or

immunoglobulin
monoclonal antibodies
bone marrow procedure
monoclonal protein
cytopenia
  • 0 views
  • 29 May, 2021
  • 1 location
TPO-Mimetic Use in Children for Hemotopoietic Failure

This is an open label, prospective Pilot interventional study will investigate the safety and efficacy of Romiplostim, thrombopoietin (TPO) mimetic, in children (ages: 0 to 21 years) with broad scope of bone marrow failure disorders including acquired and inherited conditions as a first line of therapy along with standard of …

pancytopenia
monosomy 7
reticulocyte count
severe aplastic anemia
blood transfusion
  • 0 views
  • 18 Jun, 2021
  • 1 location
ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma

have the disadvantage of having a limited HSC dose leading to prolonged cytopenia and higher risk of infections. In a first in-human trial using CB expanded with the ECT-001 (UM171) molecule

measurable disease
graft versus host disease
plasma cell leukemia
leukemia
lenalidomide
  • 65 views
  • 15 Mar, 2022
  • 1 location