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Found 37 clinical trials
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COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - Australia  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …

erythropoietin
vasectomy
cancer
epoetin alfa
  • 96 views
  • 26 Mar, 2021
  • 7 locations
Low-Dose Danazol for the Treatment of Telomere Related Diseases

Background DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes can develop diseases of the bone marrow, lung, and liver. Researchers want to …

  • 57 views
  • 08 Apr, 2021
  • 1 location
THrombo-Embolic Event in Onco-hematology

and quality of life of cancer patients. Chemotherapy is a regular generator of cytopenia, the most prominent of which is thrombocytopenia. In addition, a prospective study of 107 cancer

coagulation factor
primary cancer
deep vein thrombosis
antiplatelet therapy
anticoagulants
  • 0 views
  • 25 Jan, 2021
  • 1 location
Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by …

etoposide
trisomy
blast cells
leukemia
cytarabine
  • 153 views
  • 31 Jul, 2021
  • 142 locations
Tacrolimus Treatment for Refractory Autoimmune Cytopenia

Autoimmune cytopenia, including autoimmune hemolytic anemia (AIHA), pure red cell aplasia (PRCA), Evans syndrome (ES), usually has good responses to steroids therapies as first line, but there

  • 0 views
  • 23 Jan, 2021
  • 1 location
Umbilical Cord Blood Treatment for Refractory Immune Cytopenia

Immune-related hematocytopenia is a type of immunity Inflammatory cytopenia-mediated diseases, hormones and immunosuppressants are its first-line treatment. However, conventional

  • 0 views
  • 25 Jan, 2021
  • 1 location
Clinical Trial of a Novel Dose Adjustment Algorithm for Preventing Cytopenia-Related Delays During FOLFOX Chemotherapy

The study will test an intervention of an investigator-developed chemotherapy dose adjustment algorithm. The primary objective of this study is to evaluate the effectiveness of the chemotherapy dose adjustment algorithm for reducing unplanned delays in patients receiving FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin)-type chemotherapy, while maintaining acceptable chemotherapy dose-intensity.

folfox regimen
cetuximab
trastuzumab
cancer chemotherapy
fluorouracil
  • 0 views
  • 26 Jan, 2021
  • 1 location
Ascorbic Acid and Combination Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma or Clonal Cytopenia of Undetermined Significance

) or clonal cytopenia of undetermined significance. Ascorbic acid may make cancer cells more sensitive to chemotherapy. Drugs used in chemotherapy, work in different ways to stop the growth of cancer

etoposide
platelet count
conjugated bilirubin
HIV Infection
cytarabine
  • 17 views
  • 25 Jun, 2021
  • 7 locations
Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

The use of genomics and functional translational studies is to identify and diagnose patients with precursor features of myeloid neoplasms and inherited bone marrow failure syndromes.

  • 0 views
  • 19 Mar, 2021
  • 1 location
A Study of KER-050 to Treat Anemia Due to Very Low Low or Intermediate Risk Myelodysplastic Syndromes

The purpose of this study is to evaluate the effects of KER-050 on anemia in patients with very low, low or intermediate risk MDS.

anemia
blood transfusion
bone marrow procedure
  • 32 views
  • 26 Jan, 2021
  • 12 locations