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Found 774 clinical trials
Nutrition and Inflammation in Patients With Head and Neck Cancer

An estimated 1500 people in Sweden will annually be diagnosed with head and neck cancer (HNC). Five year survival is approximately 69%. Long-term sequelae are common and in particular nutritional problems and fatigue. Radiotherapy (RT) is the cornerstone of treatment, either as single modality treatment or combined modality treatment. RT …

neck cancer
nutritional problems
cancer
head and neck cancer
  • 9 views
  • 22 Jan, 2021
  • 1 location
Genomic and Phenotypic Determinants of Resistance to Immunotherapies in Multiple Myeloma

A total of 40 Multiple Myeloma (MM) patients at clinical relapse who progressed during Proteasome Inhibitors (PIs) or Immunomodulating Drugs (IMiDs)-based therapies and who are assigned to antiCD38-based salvage treatments, will be enrolled. We will collect bone marrow (BM) and peripheral blood (PB) samples from patients at specific timepoints: baseline …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Quantification of Bacterial DNA in Sepsis

The purpose of this study is to evaluate whether bacterial DNA clearance measured with droplet digital Polymerase Chain Reaction (ddPCR) can be used as a measure of bacterial load in septic intensive care patients. Furthermore, the aim is to examine a possible relation between clearance of bacterial DNA and clinical …

  • 0 views
  • 22 Jan, 2021
  • 1 location
Identification of Cytokine Profiles and T Cell Subsets Among Immunosuppressed Patients at Risk of Developing Active Tuberculosis

The purpose of this study is to identify differences in TB specific immune responses among immunosuppressed patients latently infected with TB and patients with active TB.

latent tuberculosis
tuberculosis
  • 4 views
  • 07 Nov, 2020
  • 1 location
Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit

Goals Primary: compare changes in norepinephrine requirements before and after hemoperfusion (HP) treatment. Secondary: demonstrate the decrease in levels of IL-6 , assess the total and individual change of SEQUENTIAL ORGAN FAILURE ASSESSMENT (SOFA), establish the resolution of shock , clearance of lactate , and mortality at discharge from INTENSIVE …

organ failure
norepinephrine
sepsis
interleukin-6
hemoperfusion
  • 0 views
  • 23 Jan, 2021
  • 1 location
Prognostic Biomarkers in Patients With Acute Pericarditis

The study will aim at investigating novel plasma or imaging biomarkers in patients with acute pericarditis. All participants will be treated according to established clinical recommendations for the diagnosis and treatment of acute pericarditis. Study participants will undergo blood sampling for measurements of plasma biomarkers potentially involved in the pathogenesis …

  • 3 views
  • 21 Jan, 2021
Etiopathogenesis of Anemia in Chronic Liver Disease

Anemia is the most common complication of liver cirrhosis and is seen in 75% of cases. The etiology of anemia in liver disease is diverse and often multi-factorial. Given the diverse and sometimes multifactorial etiology of cirrhosis, it is difficult to determine the exact cause of anemia in these groups …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Uterine Inflammatory Characteristics

Data regarding fertility following niche repair is limited. It has been reported that a niche can reduce the chances of embryo implantation and may lead to spontaneous miscarriages if the implantation is close to or in the niche. One possible theory refers to inflammatory process at the area of the …

  • 0 views
  • 02 Apr, 2021
  • 1 location
Cytokine Filter Usage During Open Thoracoabdominal Aortic Aneurysm Repair- a Single-center Randomized Prospective Trial

Prospecrtive study including 20-30 randomized patients treated by open repair because of an TAAA larger than 55 mm During the surgery, a heart lung machine is applied for distal perfusion during aortic cross clamping to enable distal organ perfusion. Regardless an intensive inflammatory reaction is a well known effect after …

  • 0 views
  • 21 Mar, 2021
  • 1 location
MIF Involvement in AML

This study is an observational study of MIF involvement in retrospectively and prospectively included adult acute myeloid leukemia (AML). Standard care samples collected at diagnosis, after one course of treatment, at time of remission controls, and at time of relapse will be used. The first objective is to determine which …

remission
adult acute myelogenous leukemia
  • 16 views
  • 23 Jan, 2021
  • 1 location