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Found 774 clinical trials
Biological Response to Brief Psychological Challenge

The investigators plan to conduct a crossover experimental trial examining physiological responses to a socio-evaluative speech task under laboratory conditions. Participants will attend two laboratory sessions. At one session participants will take part in a brief laboratory stress task and at the other participants will rest for the same period. …

  • 12 views
  • 14 Apr, 2021
  • 1 location
Clinical Research of Reducing Medication Regimen for Ursodeoxycholic Acid in Treatment of Stable Primary Biliary Cholangitis

This study explores the feasibility of the reducing medication regimen for Ursodeoxycholic Acid(UDCA) in the treatment of primary biliary cholangitis. The participants will be distributed randomly into two experimental groups and one control group. The two experimental groups will receive reduced dosage of UDCA at different level, while the control …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Chronic Recurrent Multifocal Osteomyelitis - a Bacterial Cause?

Chronic recurrent multifocal osteomyelitis (CRMO) is an immune-mediated chronic inflammatory self- limiting disease with non-suppurative inflammation involving one or multiple bone foci. A bacterial etiology has not yet been proven, but the investigators hypothesize that CRMO is caused by chronic infection. Using existing knowledge of chronic infections combined with sensitive …

  • 294 views
  • 27 Jan, 2021
  • 1 location
Safety and Tolerability Study of IV ST266 in COVID-19 Subjects

The primary aim of the study is to evaluate the safety and tolerability of open-label ST266 given to subjects with confirmed COVID-19 infection through IV administration once a day of 5 consecutive days.

  • 0 views
  • 14 Mar, 2021
  • 2 locations
NEoadjuvant Dose-dense MVAC In cOmbination With Durvalumab and Tremelimumab in Muscle-invasive Urothelial Carcinoma

This is an open label, phase I/II clinical trial to evaluate the efficacy and safety of 2 cycles of durvalumab without (Arm A) or with (Arm B) tremelimumab in association with ddMVAC as neoadjuvant therapy in patients with MIUC.

  • 3 views
  • 25 Jan, 2021
  • 20 locations
Mechanisms of LPRF Action in the Promotion of Wound Healing and Tissue Regeneration

This study evaluates the clinical and biological effects of leucocyte and platelet-rich fibrin (L-PRF) on intraoral wound healing.

fibrin
  • 1 views
  • 23 Jan, 2021
  • 1 location
Effects of Bronchial Segmental Endotoxin Instillation in Humans

Background When bacteria enter the lungs, serious infections can occur. Researchers want to learn more about the process of inflammation in the lungs by studying lung cells and the products that they make. Lung cells are influenced by infections, smoking, and molecules made within the body. Researchers also want to …

  • 0 views
  • 21 Mar, 2021
  • 1 location
Doxycycline for Hereditary Hemorrhagic Telangiectasia

This study will investigate the effectiveness of oral doxycycline for the treatment of recurrent nasal hemorrhage in Hereditary Hemorrhagic Telangiectasia (HHT) subjects. The primary outcome for the trials will be the reduction of epistaxis severity (minutes of bleeding per week). The biological outcomes of interest are the regression of vascular …

  • 2 views
  • 25 Jan, 2021
  • 1 location
Safety and Efficacy of Repetitive Peripheral Magnetic Stimulation in Patients With Achilles Tendinopathy

With this prospective, randomized, controlled trial the investigators want to investigate effects of a prolonged repetitive Peripheral Magnetic Stimulation (rPMS) intervention on Achilles tendinopathy and compare it to a well established intervention. This may provide clinicians with a new, non-pharmacological, non-invasive, near painless approach to treat tendinopathy. Although promising results …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis

This study is to evaluate the effectiveness of regenerative endodontics therapy in single-rooted permanent teeth with pulp necrosisand compare the clinical efficacy of platelet rich fibrin (PRF) and blood clot (BC) as scaffolds.

clot
blood clot
root canal therapy
fibrin
  • 0 views
  • 24 Jan, 2021
  • 3 locations