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Found 743 clinical trials
Mindfulness - Based Intervention in the Treatment of Fatigue in Patients With Primary Biliary Cholangitis

To assess the efficacy of mindfulness-based intervention (MBI) intervention in the treatment of moderate or severe fatigue in patients with primary biliary cholangitis (PBC).

cholangitis
cirrhosis
ursodiol
fatigue
  • 1 views
  • 17 Feb, 2021
  • 1 location
Magnetic Resonance Imaging of Aortic Aneurysm Instability

Abdominal aortic aneurysm (AAA) is a progressive enlargement of the aorta, the largest blood vessel in the body. It is at risk of bursting when it is usually fatal. Currently the risk of the AAA bursting is estimated from its diameter. In this study, the investigators hope to develop a …

abdominal aortic aneurysm
  • 12 views
  • 07 Nov, 2020
  • 1 location
Norplant and Irregular Bleeding/Spotting

Irregular or prolonged menstrual bleeding and/or spotting are common side effects in patients using progestin-only hormonal contraception such as levonorgestrel implants (Norplant). Doxycycline, a drug approved by the Food and Drug Administration (FDA) to treat gum disease, may reduce the occurrence of uterine bleeding and spotting in women who use …

gum disease
doxycycline
antibiotics
  • 41 views
  • 07 Nov, 2020
  • 1 location
Tumor Necrosis Factor (TNF) and Glucocorticoid Antagonist for Gulf War Illness (GWI)-Associated Multi-symptom Disease Homeostasis Reset

Gulf War Illness is a condition that affects multiple major organ systems, resulting in a diverse array of symptoms that include debilitating fatigue, memory and cognition difficulties, headaches, sleep disturbances, gastrointestinal problems, skin rashes, and musculoskeletal/joint pain. This phase I single-site, open-label two-arm study will assess the safety and mechanistic …

  • 0 views
  • 24 Jan, 2021
  • 1 location
Mechanisms of Ozone-Induced Alterations in Efferocytosis and Phagocytosis

The purpose of this research study to understand how environmental and genetic factors may be involved in lung function. Healthy Study participants will undergo a 1-day screening that includes a blood draw and breathing testing, return for a two-day series of testing to include blood draw, and brief breathing test …

  • 0 views
  • 26 Jan, 2021
Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease

Interventions that affect many different aspects of human ability rather than just one aspect of human health are more likely to be successful in preventing and treating Alzheimer's disease (AD). Functional decline in AD is severely impacted by impaired ability to do physical actions while having to make decisions and …

  • 1 views
  • 02 Feb, 2021
  • 1 location
Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)

The purpose of the study is to determine whether plinabulin (also known as BPI-2358) has an effect on cancer and body in combination with nivolumab, a standard treatment for metastatic squamous non-small cell lung cancer with progression on or after platinum-based chemotherapy. Plinabulin inhibits tumor growth by targeting both new …

systemic therapy
tumor cells
squamous non-small cell lung cancer
cancer
platinum-based chemotherapy
  • 0 views
  • 01 Mar, 2021
  • 1 location
Efficacy Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS

The purpose of this study is to compare the efficacy and safety of andrographolide 140 mg administered twice a day orally versus a placebo as a modifying treatment of the disease in patients with the progressive forms of Multiple Sclerosis (MS). The principal outcome is to determine the efficacy, of …

brain atrophy
andrographolide
atrophy
  • 10 views
  • 07 Nov, 2020
  • 1 location
Biological Response to Brief Psychological Challenge

The investigators plan to conduct a crossover experimental trial examining physiological responses to a socio-evaluative speech task under laboratory conditions. Participants will attend two laboratory sessions. At one session participants will take part in a brief laboratory stress task and at the other participants will rest for the same period. …

  • 12 views
  • 25 Jan, 2021
  • 1 location
Fostamatinib for Hospitalized Adults With COVID-19

Background COVID-19 is a new disease caused by SARS-CoV-2 that was identified in 2019. Some people who get sick with COVID-19 become ill requiring hospitalization. There are some medicines that may help with recovery. Researchers want to see if a drug called fostamatinib may help people who are hospitalized with …

  • 0 views
  • 01 Mar, 2021
  • 2 locations