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Found 781 clinical trials
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A Phase 2, Single-Arm, Open-Label Study of Itacitinib for the Prevention of Cytokine Release Syndrome Induced by Immune Effector Cell Therapy by Immune Effector Cell Therapy

The purpose of this study is to assess the safety and efficacy of oral administration of itacitinib once daily for the prevention of cytokine release syndrome (CRS) in male or female participants aged 12 years or older and who are planning to receive tisagenlecleucel or axicabtagene ciloleucel immune effector cell …

cancer
hematologic cancer
  • 74 views
  • 23 Nov, 2020
  • 10 locations
featured
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

anemia
anemia studies
myelodysplastic syndrome (mds)
aplastic anemia
myelodysplastic syndromes
  • 123 views
  • 22 Dec, 2020
  • 1 location
The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes

The endothelial dysfunction is the early event in atherosclerosis. The investigator previous study showed that impaired endothelial function exist in newly diagnosed type 2 diabetes. The investigators hypothesize that intensive multifactorial therapy including intensive blood control and intensive hypertension control as well as intensive blood lipids control of 1 year …

type 2 diabetes mellitus
hypertension
atherosclerosis
diabetes
blood lipids
  • 0 views
  • 08 Nov, 2020
  • 1 location
A Clinical Trial to Evaluate the Effectiveness of Lactobacillus Reuteri for Periodontitis in a Chinese Population

The aim of this study is to determine the efficacy of application of Lactobacillus Reuteri probiotics therapy on clinical improvement and on microbial shift in Chinese periodontitis patients.

periodontal disease
periodontal probing
  • 5 views
  • 17 May, 2020
  • 1 location
Maintaining Mechanical Ventilation During Cardiopulmonary Bypass for Cardiac Surgery

The main objective of this study is to measure the incidence of postoperative infections in 2 groups of patients: one group of patients ventilated and one group of patients without mechanical ventilation during cardiopulmonary bypass for cardiac surgery, and demonstrate that the incidence of postoperative infections is significantly lower in …

sternotomy
heart surgery
  • 12 views
  • 15 Jun, 2020
  • 6 locations
Cytokine-induced Killer Cell Immunotherapy for Surgical Resected Stage III Colorectal Cancer Patients After Chemotherapy

We hypothesize through this randomized, prospective, single center adjuvant study, that cytokine-induced killer cell in patients with stage III colon cancer can improve survival in this patient population over control. Stage III colon cancer patients can benefit most from adjuvant chemotherapy, but the 5 year survival rate is still around …

  • 11 views
  • 08 Nov, 2020
  • 1 location
Anti-thrombotics for Adults Hospitalized With COVID-19 (ACTIV-4)

This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic strategies for prevention of adverse outcomes in COVID-19 positive inpatients

  • 0 views
  • 11 Jan, 2021
  • 41 locations
Safety and Efficacy Study of Ex Vivo Immunotherapy for Treatment of Aplastic Anemia

Our hypothesis is that ex vivo activated immune cells would produce multiple known and unknown potent hematopoietic cytokines, working in concert, these cytokines help stem cell growth

cytokines
immunosuppression
bone marrow transplant
aplastic anemia
immunosuppressive agents
  • 29 views
  • 07 Nov, 2020
  • 1 location
Influence of Thyroid Hormones on the Woundhealing Process

Main goal of this clinical investigation is to investigate different cytokines in wound fluids of euthyroid vs. hypothyroid patients. As a primary endpoint we want to evaluate if

thyroidectomy
thyrotropin alpha
rhtsh
papillary thyroid carcinoma
papillary carcinoma
  • 17 views
  • 07 Nov, 2020
Prevention and Treatment of Differentiation Syndrome in Patients With Acute Promyelocytic Leukemia

dexamethasone.Furthermorethe changes of spectrum of cytokines are monitered to find the relationship between the cytokines and the severity of DS.

  • 0 views
  • 01 Jul, 2020
  • 1 location