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Found 41 clinical trials
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A Phase 2, Single-Arm, Open-Label Study of Itacitinib for the Prevention of Cytokine Release Syndrome Induced by Immune Effector Cell Therapy by Immune Effector Cell Therapy

The purpose of this study is to assess the safety and efficacy of oral administration of itacitinib once daily for the prevention of cytokine release syndrome (CRS) in male or female participants

hematologic cancer
cancer
  • 82 views
  • 23 Nov, 2020
  • 10 locations
None
A Study of Itacitinib for the Prevention of Cytokine Release Syndrome Induced by Immune Effector Cell Therapy

The purpose of this study is to assess the safety and efficacy of oral administration of itacitinib once daily for the prevention of cytokine release syndrome (CRS) in male or female

  • 2 views
  • 09 Oct, 2021
  • 13 locations
None
Safety and Tolerability Study of IV ST266 in COVID-19 Subjects

The primary aim of the study is to evaluate the safety and tolerability of open-label ST266 given to subjects with confirmed COVID-19 infection through IV administration once a day of 5 consecutive days.

  • 0 views
  • 29 Sep, 2021
  • 3 locations
None
CNCT19 Following ASCT in Patients With Relapsed or Refractory B-cell Lymphoma

The primary objective of this study is to explore the safety and efficacy of CNCT19 (a second-generation anti-CD19 CAR T-cell using 4-1BB as co-stimulatory domain provided by Juventas, Tianjin, China) infusion following ASCT in patients with relapsed or refractory B-cell lymphoma.

  • 0 views
  • 27 Jan, 2021
  • 1 location
None
Prevention and Treatment With Calcifediol of COVID-19 Induced Acute Respiratory Syndrome

The administration of Calcifediol in patients with COVID-19, will reduce the development of SARS and the worsening of the various phases of the syndrome. Reducing at least 25% in ICU admission and death from the process, reducing days of hospitalization, facilitating the recovery of the same, acting significantly and positively, …

  • 0 views
  • 03 Sep, 2021
  • 1 location
None
Study Evaluating Safety Tolerability and PK of AMG 757 in Adults With Small Cell Lung Cancer

A study to assess the safety, tolerability, and pharmacokinetics of AMG 757 in Subjects with Small Cell Lung Cancer

platinum-based chemotherapy
cancer chemotherapy
brain metastases
metastasis
delta-like protein 3
  • 398 views
  • 17 Nov, 2021
  • 65 locations
None
The Role of Resistant Starch in COVID-19 Infection

This study is a multicenter randomized trial to evaluate the efficacy of administering a dietary supplement containing resistant starch to non-hospitalized COVID-19 positive subjects, The intervention will begin as soon as possible after subjects test positive for COVID-19 and continue for 14 days. Investigators hypothesize that short-term administration of a …

covid-19
  • 65 views
  • 24 Sep, 2021
  • 2 locations
None
Cyclosporine on Day Zero as Prophylaxis for Cytokine Release Syndrome

incidence of cytokine release syndrome (CRS) in patients who receive an outpatient haploidentical transplant.

  • 0 views
  • 11 Mar, 2021
  • 1 location
None
Extracorporeal Cytokine Adsorption as Additive Treatment of CAR-T Associated Cytokine Release Syndrome (CRS)

Patients with severe CAR-T cell associated cytokine release syndrome (CRS) (defined as vasopressor dependent) will be treated with standard of care (SOC) + cytokine adsorption (6hourly for 24

  • 0 views
  • 10 Apr, 2021
  • 2 locations
None
Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

This study will evaluate the use of siltuximab to decrease the severity of cytokine release syndrome (CRS) and immune effector cell-associated neurological syndrome (ICANS) in patients who will

  • 0 views
  • 03 Dec, 2021
  • 1 location