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Found 17 clinical trials
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Background Severe aplastic anemia (SAA) is a rare and serious blood disorder. It causes the immune system to turn against bone marrow cells. Standard treatment for SSA is a combination of 3 drugs (Cyclosporine [CsA], Eltrombopag [EPAG], and horse anti-thymocyte globulin [h-ATG]). Researchers want to see if starting people at …

immunosuppressant
aplastic anemia
antithymocyte globulin
neutrophil count
immunosuppression
  • 1 views
  • 27 Feb, 2021
  • 1 location
RCT Study to Validate niPGT-A Clinical Benefit.

Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidy are reported to prevent implantation. Thus, there is a need to identify the embryos with highest implantation potential on in vitro fertilization (IVF) programs. Since embryo morphology and kinetics have a …

discomfort
intracytoplasmic sperm injection
embryo culture
in vitro fertilization
  • 717 views
  • 27 Jan, 2021
  • 21 locations
Study for Patients With Newly Diagnosed High-risk Acute Promyelocytic Leukemia

APL is designated as"M3 leukemia" and assigned to the WHO defined type of AML with recurrent cytogenetic abnormalities, "acute promyelocytic leukemia with t(15;17)(q22;q12), (PML/RAR) and variants

anthracyclines
serum bilirubin
hysterectomy
cytarabine
myeloid leukemia
  • 0 views
  • 23 Jan, 2021
  • 8 locations
Acalabrutinib and High Frequency Low Dose Subcutaneous Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma

The main purpose of this research study is to find out if the combination of acalabrutinib and high frequency low dose subcutaneous rituximab is safe and effective in patients who have previously untreated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).

acalabrutinib
neutrophil count
corticosteroids
fever
lymphoma
  • 3 views
  • 12 Feb, 2021
  • 1 location
A Study of Azacitidine for Patients With Int/High -Risk MDS and AML-MRC

evaluate the clinical efficacy and safety of azacitidine combined with HAG regimen for patients with int/high -risk MDS and AML-MRC with less than 30% blasts compared with azacitidine

  • 7 views
  • 22 Jan, 2021
  • 1 location
Interferon for the Therapy of Minimal Residual Disease

This study aimed to evaluate the efficacy of interferon among patients undergone unmanipulated blood and marrow transplantation following day 60 post-transplantation who were minimal residual disease positive after transplantation. Hematopoietic stem cell transplantation (HSCT) is an effective treatment option for acute leukemia and many other hematological malignancies. However, post-transplant relapse …

cell transplantation
hematologic malignancy
acute leukemia
myeloid leukemia
cancer
  • 0 views
  • 22 Jan, 2021
  • 1 location
IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome

patients with MDS (Myelodysplastic Syndrome) and mutated IDH1 patients will be treated with AG120 (IDH1 inhibitor)

blood transfusion
azacitidine
blast cells
ejection fraction
cytopenia
  • 7 views
  • 25 Mar, 2021
  • 54 locations
IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome

patients with MDS (Myelodysplastic Syndrome) and mutated IDH2 patients will be treated with AG221 (IDH2 inhibitor)

blood transfusion
cell transplantation
hydroxyurea
blast cells
colony stimulating factor
  • 4 views
  • 27 Jan, 2021
  • 30 locations
Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia

RATIONALE: Giving chemotherapy and colony-stimulating factors, such as G-CSF, may increase the number of stem cells in the blood. The stem cells are collected from the patient's blood and stored. Chemotherapy or radiation therapy is given to prepare the bone marrow for the stem cell transplant. The stem cells are …

cell transplantation
busulfan
myeloid leukemia
granulocyte colony stimulating factor
sargramostim
  • 24 views
  • 03 Feb, 2021
  • 1 location
Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations

Background GATA2 deficiency is a disease caused by mutations in the GATA2 gene. It can cause different types of leukemia and other diseases. Researchers want to see if a stem cell transplant can be used to treat this condition. A stem cell transplant will give stem cells from a matching …

ejection fraction
direct bilirubin
total body irradiation
remission
filgrastim
  • 26 views
  • 01 May, 2021
  • 1 location