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Found 161 clinical trials
Combination of Sorafenib With Standard Therapy in Newly Diagnosed Adult CBF AML

Core-binding factor acute myeloid leukemia accounts for 10-15% of AML and is categorized as favorable-risk AML. However, the 5-year CIR was up to 40% in this group of patients. Emerging data show that a high frequency of mutations and/or high expression of KIT in CBF AML. Sorafenib is a multitargeted …

  • 0 views
  • 17 Jun, 2022
  • 1 location
Efficacy of Intermediate-Dose Cytarabine Induction Regimen in Adult AML

intermediate dose of cytarabine. In the control arm, patients receive DA regimen with standard dose of cytarabine.The efficacy of induction therapy containing intermediate dose of cytarabine is evaluated and

cytarabine/daunorubicin
neoadjuvant therapy
daunorubicin
cytarabine
adult acute myelogenous leukemia
  • 36 views
  • 25 Feb, 2022
  • 1 location
Idarubicin Plus Cytarabine (IA) vs IA Plus Cladribine (IAC) as Induction Regimen to Treat Initially Diagnosed Acute Myeloid Leukemia (AML)

The purpose of this study is to compare the clinical efficacy and safety of IAC regimen and IA regimen as induction chemotherapy for initial diagnosed AML patients. 840 cases are supposed to recruited in 3 years.

cladribine
induction chemotherapy
cytarabine
idarubicin
ara-c
  • 26 views
  • 24 Jan, 2021
  • 1 location
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia (Myechild01)

with cytarabine plus mitoxantrone or liposomal daunorubicin in induction To compare mitoxantrone (anthracenedione) & cytarabine with liposomal daunorubicin (anthracycline) &amp

ejection fraction
gilbert's syndrome
idarubicin
busulfan
mitoxantrone
  • 0 views
  • 26 Jan, 2022
  • 69 locations
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Background Researchers are testing version of a system known as a magnetic resonance imagining (MRI) scanner that uses strong magnetic fields, radio waves and the like to create images of the organs in the body. It uses lower energy levels than other MRI scanners. This may help scan people with …

ejection fraction
chest pain
infarct
Accepts healthy volunteers
cancer
  • 114 views
  • 25 Jul, 2022
  • 1 location
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acute myeloid

anthracyclines
cell transplantation
cancer
cytarabine
daunorubicin
  • 141 views
  • 10 May, 2022
  • 98 locations
An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 When Administered Alone and in Combination With Low-Dose Cytarabine (LDAC) or Decitabine in Patients With Acute Myeloid Leukemia (AML)

This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, when administered alone and in combination with low-dose cytarabine (LDAC) or Decitabine for the treatment of adults

cancer
decitabine
cytarabine
refractory acute myeloid leukemia (aml)
  • 2 views
  • 17 Jun, 2022
  • 55 locations
Study to Improve OS in 18 to 60 Year-old Patients Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR

This open label, multicenter phase II/III study with multiple randomization phases at differents stages of AML treatment (induction, consolidation and HSCT where applicable) is designed to improve OS in younger (18 to 60 year-old) patients, with AML risk-adapted patient strategies. Within the intermediate risk AML group, optimal GvHD prophylaxis following …

colony stimulating factor
cyclosporine
consolidation chemotherapies
venetoclax
cancer
  • 42 views
  • 25 Jan, 2021
  • 57 locations
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in different ways

blinatumomab
dexamethasone
asparaginase
mercaptopurine
monoclonal antibodies
  • 92 views
  • 27 Jul, 2022
  • 119 locations
A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children, Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)

tolerated dose (MTD) for gilteritinib in sequential combination with fludarabine, cytarabine and granulocyte colony-stimulating factor (FLAG). The purpose of the phase 2 portion (dose expansion) is to

fludarabine
hematopoietic growth factors
hydroxyurea
tyrosine
cytarabine
  • 6 views
  • 22 Jul, 2022
  • 18 locations