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Found 51 clinical trials
Bendamustine With or Without Cyclophosphamide in Preventing GVHD in Patients Undergoing Stem Cell Transplant

This phase I/II trial studies the side effects and best dose of bendamustine when given with or without cyclophosphamide in preventing graft versus host disease (GVHD) in patients undergoing stem cell transplant. Drugs used in chemotherapy, such as bendamustine and cyclophosphamide, work in different ways to stop the growth of …

carbon monoxide
fludarabine
melphalan
filgrastim
tacrolimus
  • 6 views
  • 22 Mar, 2022
  • 1 location
Sacral Neuromodulation for Pelvic Pain Associated With Endometriosis

The purpose of this study is to find out if sacral neuromodulation is an effective treatment for pelvic pain associated with surgically treated endometriosis.

endometriosis surgery
pelvic pain
pelvic mri
transvaginal ultrasound
endometriosis
  • 0 views
  • 28 May, 2021
  • 1 location
Efficacy of Corticosteroids in Reducing Renal Scarring in Acute Pyelonephritis in Children

Urinary tract infection (UTI) is the most frequently occurring serious bacterial infection in young children and accounts 5 to 14% of emergency department visits Formation of renal scarring in children has been associated with serious complications as hypertension, preeclampsia, and end stage renal failure in young age . So, this …

antibiotics
pyelonephritis
fever
acute pyelonephritis
Accepts healthy volunteers
  • 2 views
  • 29 Apr, 2022
  • 1 location
Methods of T Cell Depletion Trial (MoTD)

A multi-centre phase II trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin vs. Calcineurin inhibitor or Sirolimus-based post-transplant cyclophosphamide.

  • 0 views
  • 24 May, 2021
  • 1 location
Adoptive Cord Blood Immunotherapy for EBV, CMV, BKV and Adenovirus Reactivation/Infection or Prophylaxis

This Phase I-II dose-finding trial to determine the optimal dose of intravenous (IV) injection dose of donor-derived cytotoxic T lymphocytes (CTLs) specific for CMV, EBV, BKV and Adenovirus. A maximum of 36 patients will be treated in up to 18 cohorts each of size 2, with the first cohort treated …

absolute neutrophil count
nephropathy
cmv infection
  • 63 views
  • 05 Mar, 2022
  • 2 locations
T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation (NATS)

This Phase I dose-escalation trial is designed to evaluate the safety of rapidly generated multivirus-specific T-cell products with antiviral activity against CMV, EBV, adenovirus, HHV6, BK virus, JC virus, and human parainfluenza-3 (HPIV3), derived from eligible HSCT donors. In this trial, we will utilize a rapid generation protocol for broad …

stem cell transplantation
prednisone
cmv infection
antiviral drugs
parainfluenza
  • 54 views
  • 25 Feb, 2022
  • 1 location
ABM/P-15 Bone Graft vs Traditional Bone Graft in Adult Spinal Deformity Surgery

The purpose of this prospective trial is to investigate ABM/P-15 bone graft versus traditional bone graft in patients undergoing surgery for Adult Spinal Deformity (ASD) in order to provide better clinical results through faster bone healing, no additional surgeries, fewer complications and thereby increase health-related quality of life. Main hypotheses: …

  • 0 views
  • 22 Mar, 2022
Urine Biomarker for Stone Recurrence

Despite the advent of treating stones with Extracorporeal Shock Wave Lithotripsy (ESWL) and Percutaneous nephrolithotomy (PCNL), the recurrence rate for renal stones remains high and this may be due to poor compliance of patients with dietary and fluid advice, age, metabolic abnormalities, medicines and the formation of "new stones" from …

lithotripsy
percutaneous nephrolithotomy
shock
nephrolithiasis
  • 0 views
  • 11 Aug, 2021
  • 1 location
A Study of Pentosan Polysulfate Sodium and the Development of Pigmentary Maculopathy and Pigmentary Retinopathy

[PPS], and PM/PR/Non-PPS) in relation to PPS exposure, and in participants with interstitial cystitis (IC) but not exposed to PPS; changes in visual acuity (VA) over time; participant treatment journey

pentosan polysulfate
retinopathy
  • 0 views
  • 10 May, 2022
  • 1 location
Treatment Outcomes Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction

have formulated a treatment protocol based on the current literatures on the management of voiding dysfunction and also a similar condition, interstitial cystitis / painful-bladder syndrome (IC/PBS

of substance abuse
drug abuse
substance of abuse
analgesia
ketamine
  • 143 views
  • 04 Mar, 2022
  • 1 location