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Found 46 clinical trials
The Safety Tolerability and Efficacy of LP-10 in Subjects With Refractory Moderate to Severe Hemorrhagic Cystitis

The purpose of this study is to assess the safety and tolerability of three doses of LP-10 (intravesical tacrolimus). Twelve subjects meeting the inclusion and exclusion criteria will be enrolled and treated in a prospective and multi-center trial with LP-10. The proposed trial will recruit 12 subjects in a dose-escalation …

  • 0 views
  • 25 Jan, 2021
  • 2 locations
Tolerability and Efficacy of INSTYLAN in Subjects With Moderate to Severe Hemorrhagic Cystitis

The purpose of this study is to assess the efficacy and tolerability of INSTYLAN (Sodium Hyaluronate 80mg/50ml) in Patients with early or late symptoms of moderate to severe hemorrhagic cystitis

  • 0 views
  • 28 Jan, 2021
  • 10 locations
Study to Evaluate Viralym-M (ALVR105) for the Treatment of Virus-Associated Hemorrhagic Cystitis (HC)

A study to evaluate Viralym-M; an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets six viral pathogens: BK virus, cytomegalovirus, adenovirus, Epstein-Barr virus, human herpesvirus 6 and JC virus.

  • 0 views
  • 28 Jan, 2021
  • 12 locations
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease PRD) Refractory to Standard Therapy

%) and radiation-induced cystitis (3,5%) that affect quality of life. The treatment of PRD is limited to managing the symptoms; new alternatives should be proposed. Clinical trials using MSCs to

  • 0 views
  • 23 Jan, 2021
  • 2 locations
Alternative Prophylaxis in Female Recurrent Urinary Tract Infections

(HA) and chondroitin sulphate (CS) obtained positive outcomes in the treatment of overactive bladder, radiation cystitis and interstitial cystitis by replenishment of the glycosaminoglycan layer of

urine culture
antimicrobials
cystitis
recurrent urinary tract infection
antibiotic therapy
  • 0 views
  • 26 Jan, 2021
  • 2 locations
Botox on Vulvar Vestibulitis

The study seeks to evaluate the effect of botulinum toxin on vulvar vestibulitis (VVS) after local injection with Botox, a potential treatment to relieve patients of vulvar pain, reducing the need for painkillers, and improving the sexual quality of life of the patients.

botulinum toxin
botox
analgesic
local injection
vulvodynia
  • 4 views
  • 07 Nov, 2020
  • 1 location
Gynaecological Disorders in Not-celiac Wheat Sensitivity

In the last few years, a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or wheat allergy. This clinical condition has been named non-celiac gluten sensitivity (NCGS), …

  • 0 views
  • 25 Jan, 2021
  • 2 locations
Bendamustine With or Without Cyclophosphamide in Preventing GVHD in Patients Undergoing Stem Cell Transplant

This phase I/II trial studies the side effects and best dose of bendamustine when given with or without cyclophosphamide in preventing graft versus host disease (GVHD) in patients undergoing stem cell transplant. Drugs used in chemotherapy, such as bendamustine and cyclophosphamide, work in different ways to stop the growth of …

fludarabine
hematologic malignancy
graft versus host disease
cancer
rituximab
  • 6 views
  • 29 Jan, 2021
  • 1 location
Cystoscopy Plus Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding

Urethral dilatation is a commonly undertaken intervention for a variety of urinary complaints including overactive bladder symptoms. There is however very little evidence for its efficacy, and no randomized trial evidence. The aim of this study is to ascertain the effect of urethral dilatation on overactive bladder symptoms and on …

urethral dilatation
bladder symptoms
anticholinergics
  • 3 views
  • 07 Nov, 2020
  • 1 location
Ketamine Treatment Effects on Synaptic Plasticity in Depression

Depression is the leading cause of disability globally (1, 2). One-third to one-half of patients suffering from major depressive disorder (MDD) do not achieve remission even after multiple antidepressant trials (3). Ketamine is a commonly-used FDA-approved anesthetic medication that at subanesthetic doses leads to rapid antidepressant and anti-suicidal ideation effects …

major depressive disorder
depressed mood
suicidal
antidepressants
ketamine
  • 0 views
  • 25 Jan, 2021