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Found 26 clinical trials
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Role of Genetic Factors in the Pathogenesis of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

pulmonary fibrosis
pulmonary disease
bronchoscopy
diabetes
  • 120 views
  • 23 Nov, 2020
  • 1 location
Study of Safety Tolerability Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

The purpose of this study is to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in patients with bronchiectasis will demonstrate

combinations
cystic fibrosis
fibrosis
spirometry
pulmonary function test
  • 0 views
  • 17 Sep, 2021
  • 10 locations
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops

CHED- Congenital Endothelial Endothelial Dystrophy is a condition that causes corneal cloudiness. Since, currently only surgery is being done to cure this condition, we are taking up the research of using topical eye drops for this condition which is a very simple and easy method. Also, there are no significant …

  • 0 views
  • 27 Apr, 2021
  • 1 location
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis

Cystic Fibrosis Related Diabetes has been identified by the CF community as one of the top ten priorities for CF research. In CF clinical decline due to dysglycemia begins early, prior to diagnosis of diabetes and increases mortality from pulmonary disease. There is presently no way to determine who, of …

  • 0 views
  • 24 Jan, 2021
  • 1 location
A Study to Evaluate the Safety Pharmacokinetics and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation

initiation and have an ivacaftor-responsive CF transmembrane conductance regulator (CFTR) gene mutation.

sweat test
fibrosis
ivacaftor
  • 0 views
  • 28 Jan, 2021
  • 23 locations
Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy

Despite the increasingly common use of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies in treating CF, it is still largely unknown whether or not other chronic

forced expiratory volume
elexacaftor
cystic fibrosis transmembrane conductance regulator
tezacaftor
fibrosis
  • 55 views
  • 26 Jan, 2021
  • 74 locations
New Markers of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function in Sweat

The aim of the study is to identify new biomarkers of CFTR function in sweat and in sweat gland.

oximetry
forced expiratory volume
cystic fibrosis transmembrane conductance regulator
fibrosis
diagnostic procedures
  • 6 views
  • 04 Apr, 2021
  • 1 location
Glycerol Phenylbutyrate Corrector Therapy For CF (Cystic Fibrosis)

transmembrane conductance regulator (CFTR)-mediated chloride transport during the nasal potential difference (NPD) test. Funding source FDA Office of Orphan Products Development.

oximetry
bronchodilator
cystic fibrosis transmembrane conductance regulator
spirometry
antibiotic therapy
  • 27 views
  • 17 Mar, 2021
  • 4 locations
Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)

The purpose of this study is to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in subjects with COPD will be efficacious with regards

bronchodilator
airway obstruction
cystic fibrosis
spirometry
bronchitis
  • 0 views
  • 15 Sep, 2021
  • 10 locations
Portal Hypertension and Systemic Endothelial Function

CFTR (Cystic Fibrosis Transmembrane conductance Regulator) protein is expressed on the surface of endothelial cells. The investigators hypothesize that liver disease related to PHT-associated cystic

portosystemic shunt
stiffness
cystic fibrosis transmembrane conductance regulator
fibrosis
hepatitis
  • 5 views
  • 25 Jan, 2021
  • 1 location