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Found 4 clinical trials
A Phase 3, Multicenter, Open-Label, Single-Arm Study of Bentracimab (PB2452) in Ticagrelor-Treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure (REVERSE-IT Trial) (REVERSE-IT)

This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. Approximately 200 patients will be enrolled from approximately 200 centers in North America, …

stroke
ticagrelor
haemostasis
coronary artery bypass graft
packed red blood cells
  • 65 views
  • 11 Oct, 2022
  • 61 locations
Naloxegol Health Outcome Post Authorisation Safety Study

This post-authorization observational safety study (PASS) monitors clinically important identified and potential risks within a cohort of patients treated with naloxegol, including the occurrence of bowel perforation, acute myocardial infarction (MI), stroke, cardiovascular (CV)-specific mortality, all-cause mortality, hypertension, opioid withdrawal, abdominal pain, diarrhea, syncope, and change in pain severity. This …

syncope
hypertension
abdominal pain
naloxegol
laxative
  • 0 views
  • 26 Jan, 2022
  • 3 locations
Pharmacokinetics of Venetoclax in Patients With Chronic Lymphocytic Leukemia

Venetoclax is a treatment for chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, the pharmacokinetic data in Chinese population, as well as the change of venetoclax plasma concentration while taking CYP enzyme inducers or inhibitors, remained unknown so far. Therefore, the aim of this study is to investigate …

cancer
chronic lymphocytic leukemia
venetoclax
  • 0 views
  • 03 Nov, 2021
  • 1 location
Pharmacokinetics of Venetoclax in Patients With Acute Myeloid Leukemia

Venetoclax is a treatment for chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, the pharmacokinetic data in Chinese population, as well as the change of venetoclax plasma concentration while taking CYP enzyme inducers or inhibitors, remained unknown so far. Therefore, the aim of this study is to investigate …

cancer
venetoclax
  • 0 views
  • 03 Nov, 2021
  • 1 location