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Found 562 clinical trials
Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more …

conventional surgery
combination chemotherapy
dactinomycin
vinorelbine
etoposide
  • 103 views
  • 07 Nov, 2020
  • 9 locations
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. A donor stem cell transplant may replace the patient's immune cells …

cyclophosphamide
asparaginase
lymphoid leukemia
dexamethasone
thioguanine
  • 0 views
  • 07 Nov, 2020
  • 1 location
Observation Combination Chemotherapy Radiation Therapy and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. An autologous stem cell transplant may …

combination chemotherapy
vindesine
x-rays
vincristine
tumor cells
  • 30 views
  • 07 Nov, 2020
  • 28 locations
Fulvestrant Versus Fulvestrant Plus Palbociclib in Operable Breast Cancer Responding to Fulvestrant

This is a multicenter, international, double-blind randomized Phase III study to evaluate the pathological complete response (pCR) according to Chevalier classification between Fulvestrant and the combination of Fulvestrant plus Palbociclib as neoadjuvant therapy of hormone-sensitive patients with operable luminal breast cancer. Eligible patients will be assessed upfront using the OncotypeDX …

progesterone
white blood cells
goserelin 3.6 mg
fulvestrant
estrogen
  • 161 views
  • 22 Jan, 2021
  • 14 locations
Chemotherapy Before and After Surgery in Treating Children With Wilm's Tumor

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving combination chemotherapy before surgery may shrink the tumor so it can be removed during surgery. Giving more chemotherapy after surgery may kill any remaining tumor cells. It is not …

conventional surgery
cyclophosphamide
tumor cells
nephroblastoma
  • 9 views
  • 07 Nov, 2020
  • 1 location
Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer

n the present study the neoadjuvant approach with the anti-HER2 trastuzumab and pertuzumab combined with carboplatin and paclitaxel will be used to compare the Event-Free Survival (EFS) in regimens with and without atezolizumab. Following the neoadjuvant part of the study, after surgery all patients will continue to receive trastuzumab and …

cyclophosphamide
progesterone
sentinel lymph node biopsy
sentinel node
residual tumor
  • 17 views
  • 24 Jan, 2021
  • 51 locations
Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Non-infectious intermediate, posterior, and panuveitides are chronic, potentially-blinding diseases. Vision-threatening cases require long-term therapy with oral corticosteroids and immunosuppression. Based upon preliminary data, adalimumab, a fully-human, anti-TNFmonoclonal antibody, now US FDA-approved for uveitis treatment, may be a superior corticosteroid-sparing agent than conventional immunosuppressive drugs. The ADVISE Trial is multicenter randomized, …

tacrolimus
tumor necrosis factor
monoclonal antibodies
methotrexate
prednisone
  • 103 views
  • 24 Jan, 2021
  • 27 locations
Combination Chemotherapy With or Without Filgrastim Before Surgery High-Dose Chemotherapy and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma

RATIONALE: Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of …

colony stimulating factor
busulfan
monoclonal antibodies
combination chemotherapy
vincristine
  • 46 views
  • 07 Nov, 2020
  • 15 locations
Vincristine Dactinomycin and Cyclophosphamide in Treating Patients With Embryonal Rhabdomyosarcoma

RATIONALE: Drugs used in chemotherapy, such as vincristine, dactinomycin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by

tumor cells
dactinomycin
combination chemotherapy
  • 53 views
  • 07 Nov, 2020
  • 2 locations
Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS)

This study will evaluate the Efficacy and Safety of Infliximab versus Cyclophosphamide in Subjects with Idiopathic Refractory Scleritis. The term scleritis describes a chronic

  • 0 views
  • 24 Jan, 2021
  • 1 location