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Found 67 clinical trials
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer (UPLIFT)

The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer. The intervention is an educational video and question prompt list (QPL) to promote communication between patients, caregivers, and the oncology team about the risks and benefits …

Accepts healthy volunteers
  • 0 views
  • 07 Oct, 2022
  • 1 location
Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors

This phase I trial studies the best dose of sonidegib when given together with pembrolizumab and to see how well they work in treating patients with solid tumor that has spread to other places in the body (advanced). Sonidegib may stop the growth of tumor cells by blocking some of …

pd-l1
systemic chemotherapy
monoclonal antibodies
direct bilirubin
stage iv non-small cell lung cancer
  • 0 views
  • 07 Oct, 2022
  • 3 locations
Intratumoral Administration of Daromun in Non-melanoma Skin Cancer Patients (DUNCAN)

This clinical phase II study is designed to investigate the efficacy of intratumorally administered L19IL2/L19TNF in patients with injectable lesions of BCC or cSCC. Favorable tumor responses following intralesional treatment with L19IL2/L19TNF have been observed in patients with injectable melanoma lesions of stage III or IV, for injected and non-injected …

metastasis
melanoma skin
skin cancer
carcinoma of skin
cancer
  • 0 views
  • 01 May, 2022
  • 3 locations
CemiplimAb Survivorship Epidemiology (CASE)

The objectives of the study are: To describe the effectiveness of cemiplimab 350 mg administered every 3 weeks (Q3W) for treatment of patients with advanced cutaneous squamous cell

exposure to radiation
cemiplimab
  • 36 views
  • 09 May, 2022
  • 44 locations
How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes (MINING)

The purpose of this research study is to examine the relationship between the microbiota (microscopic organisms) in the gut and the activity of the immune system during skin cancer immunotherapy.

skin cancer
cancer
  • 32 views
  • 31 Jan, 2022
  • 1 location
Decisional Conflicts, Health-related QoL and Satisfaction With Care in High-risk cSCC in the Head-neck Region

Patient reported outcomes in patients with high-risk cutaneous squamous cell carcinoma in the head-neck region are an important part of the complex care for these patients. Health-related

carcinoma
skin cancer
primary tumor
squamous cell carcinoma
cancer
  • 0 views
  • 04 Oct, 2022
  • 2 locations
Clinical Benefit and Biomarker Analysis of Combination of PD-1/PD-L1 Immune Checkpoint Inhibitors and Radiotherapy

Inhibitors of the programmed cell death protein 1 (PD-1)/PD-L1 immune checkpoint signaling pathway are already approved in the treatment of various tumor entities in relapsed or metastatic stages. Different exploratory trials suggest that the combination of radiotherapy and PD-1/PD-L1 inhibitors is highly effective, especially in oligometastatic stages and if all …

immunomodulator
programmed cell death protein 1
programmed cell death 1 ligand 1
solid tumour
  • 0 views
  • 28 May, 2021
  • 1 location