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Found 58 clinical trials
A First-in-Human Study of CDK-002 (exoSTING) in Subjects With Advanced/Metastatic Recurrent Injectable Solid Tumors

, injectable solid tumors with emphasis on head and neck squamous cell cancer (HNSCC), triple negative breast cancer (TNBC), anaplastic thyroid carcinoma (ATC) and cutaneous squamous cell carcinoma (cSCC).

  • 0 views
  • 26 Jan, 2021
Cemiplimab in Treating Participants With Recurrent Stage III-IV Head and Neck Squamous Cell Cancer Before Surgery

This phase II trial studies how well cemiplimab works before surgery in treating participants with stage III-IV head and neck squamous cell cancer that has come back. Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of …

  • 30 views
  • 23 Jan, 2021
  • 1 location
Safety Proliferation and Persistence of GEN-011 Autologous Cell Therapy

GEN-011 is an experimental treatment being evaluated in adult patients with advanced cancer. GEN-011 is a T cell therapy made specific to each patient, using the patient's own circulating immune cells. First, Genocea finds which cancer proteins are recognized already by the patient's T cells using ATLAS. Then, immune cells …

urothelial carcinoma
interleukin 2
melanoma skin
cyclophosphamide
fludarabine
  • 0 views
  • 28 Jan, 2021
  • 2 locations
Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

This phase II trial studies how well pembrolizumab works in treating patients with rare tumors that cannot be removed by surgery or have spread to other parts of the body. Monoclonal antibodies, such as pembrolizumab, may block specific proteins found on white blood cells which may strengthen the immune system …

carcinoma
neutrophil count
antibody therapy
metastasis
erythropoietin
  • 0 views
  • 29 Jan, 2021
  • 1 location
Tacrolimus Nivolumab and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

This phase I trial studies how well tacrolimus, nivolumab, and ipilimumab work in treating kidney transplant recipients with cancer that cannot be removed by surgery (unresectable) or has spread to other places in the body (metastatic). Tacrolimus may stop the growth of tumor cells by blocking some of the enzymes …

  • 1 views
  • 03 Feb, 2021
  • 5 locations
Study Evaluating GZ17-6.02 in Patients With Advanced Solid Tumors or Lymphoma

This study will evaluate the safety, pharmacokinetics, and pharmacodynamic effects of a novel anti-cancer drug, GZ17-6.02 administered to patients with advanced solid tumors or lymphoma, which have progressed after receiving standard/approved therapy or where there is no approved therapy.

cancer drug
metastasis
kidney function test
gz17-6.02
warfarin
  • 24 views
  • 26 Jan, 2021
  • 3 locations
Safety Tolerability Pharmacokinetics and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB099280 in participants with select solid tumors

solid tumour
solid tumors
  • 0 views
  • 28 Jan, 2021
  • 7 locations
Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers

This phase II trial studies how well talimogene laherparepvec and nivolumab work in treating patients with lymphomas that do not responded to treatment (refractory) or non-melanoma skin cancers that have spread to other places in the body (advanced) or do not responded to treatment. Biological therapies, such as talimogene laherparepvec, …

biological therapy
neutrophil count
systemic therapy
merkel cell carcinoma
melanoma skin
  • 453 views
  • 24 Feb, 2021
  • 19 locations
A Phase 1b Dose Escalation/Expansion Study of Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies

This phase I trial studies the best dose and side effects of abexinostat and how well it works with given together with pembrolizumab in treating participants with microsatellite instability (MSI) solid tumors that have spread to other places in the body. Abexinostat may stop the growth of tumor cells by …

monoclonal antibody therapy
neutrophil count
pd-l1
metastasis
systemic therapy
  • 18 views
  • 25 Jan, 2021
  • 1 location
CIMAvax Vaccine Nivolumab and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

This phase I/II trial studies the best dose and side effects of recombinant human EGF-rP64K/montanide ISA 51 vaccine (CIMAvax) and nivolumab and to see how well they work in treating patients with non-small cell lung cancer or squamous head and neck cancer that has spread to other places in the …

neutrophil count
pd-l1
metastasis
recombinant human egf-rp64k/montanide isa 51 vaccine
cancer treatment
  • 25 views
  • 25 Jan, 2021
  • 1 location