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Found 58 clinical trials
High-Risk Skin Cancers With Atezolizumab Plus NT-I7

-risk melanoma, Merkel Cell Carcinoma (MCC) and cutaneous Squamous Cell Carcinoma (cSCC)

mek inhibitor
atezolizumab
systemic therapy
carcinoma
braf inhibitor
  • 14 views
  • 25 Jan, 2021
  • 5 locations
A Study of ALKS 4230 With Pembrolizumab in Head and Neck Cancer

The primary objective of this study is to estimate the response rate to ALKS 4230 in combination with pembrolizumab in patients with HNSCC who have previously received anti-PD-(L)1 therapy but who have not achieved a CR.

  • 0 views
  • 26 Jan, 2021
  • 6 locations
Study of Metabolic Changes in the Transformation Malignant Precancerous Skin Lesions

Skin carcinomas are the most frequent cancers in the world, including basal cell carcinomas and cutaneous squamous cell carcinoma (cSCCs), with more than 60.000 new annual cases in France. Their

skin lesions
skin lesion
squamous cell carcinoma
cancer
metastasis
  • 0 views
  • 24 Jan, 2021
A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck

To evaluate the tumour response rate of squamous cell carcinoma of the head and neck following stereotactic body radiotherapy (SBRT) of 45Gy in 5 fractions delivered once every 3-4 days, such that treatment is completed within 15 days.

  • 0 views
  • 27 Jan, 2021
  • 1 location
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors

cutaneous squamous cell carcinoma.

measurable disease
EGFR
pembrolizumab
cancer
  • 0 views
  • 28 Jan, 2021
  • 3 locations
Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma Cutaneous Squamous Cell Carcinoma or Other Advanced Solid Tumors

cavrotolimod injections alone and in combination with intravenous pembrolizumab or cemiplimab in patients with Merkel Cell Carcinoma, cutaneous squamous cell carcinoma, and advanced solid tumors. Phase

  • 56 views
  • 30 Jan, 2021
  • 17 locations
Gabapentin Methadone and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

This trial studies how well gabapentin, methadone, and oxycodone with or without venlafaxine hydrochloride work in managing pain in participants with stage II-IV squamous cell head and neck cancer undergoing chemoradiation therapy. Gabapentin may reduce the need for these pain medications if given at the start of radiation therapy. Methadone …

  • 34 views
  • 04 Mar, 2021
  • 1 location
A PD-1 Checkpoint Inhibitor (Cemiplimab) for High-Risk Localized Locally Recurrent or Regionally Advanced Skin Cancer

This phase II trial studies how well cemiplimab before surgery works in treating patients with skin cancer that is high-risk and has not spread to other parts of the body (localized), has come back locally (locally recurrent), or has spread regionally (regionally advanced), and can be removed by surgery (resectable). …

  • 0 views
  • 26 Jan, 2021
  • 3 locations
Cobimetinib and Atezolizumab in Treating Participants With Advanced or Refractory Rare Tumors

This phase II trial studies how well cobimetinib and atezolizumab work in treating participants with rare tumors that have spread to other places in the body (advanced) or that does not respond to treatment (refractory). Cobimetinib may stop the growth of tumor cells by blocking some of the enzymes needed …

pleural effusion
atezolizumab
neuropathy
serum pregnancy test
carcinoma
  • 50 views
  • 02 Feb, 2021
  • 2 locations
Study of TVEC in Patients With Cutaneous Squamous Cell Cancer

This is single arm a Phase 2, single center study of talimogene laherparepvec (TVEC) to treat low risk cutaneous squamous cell carcinomas (cSCC).

growth factor
serum pregnancy test
carcinoma
anticoagulant therapy
serum bilirubin
  • 11 views
  • 24 Jan, 2021
  • 1 location