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Found 43 clinical trials
"Phase III Randomized Trial Comparing D2 vs D3 Lymphadenectomy With Gastric Cancer Following Neoadjuvant Chemotherapy

Stomach cancer is the second most common cause of cancer-related deaths in India. Curative surgery offers the only chance of improving survival in this cancer. In patients whose cancer has not

cancer chemotherapy
ct scan
gastric adenocarcinoma
  • 14 May, 2022
  • 1 location
Oral Green Tea Extract and Milk Thistle Extract to Colorectal Cancer Patients Undergoing Resection

Colorectal cancer is the third most common form of cancer found in the United States. To date surgical resection provides the best chance for cure. Unfortunately, despite "curative" surgery

cancer surgery
rectal carcinoma
  • 04 Mar, 2021
  • 1 location
Nivolumab Plus Ipilimumab as Neoadjuvant Therapy for Hepatocellular Carcinoma (HCC)

Objectives To evaluate the efficacy, in terms of tumor shrinkage, objective response rate, and down-stage rate, of nivolumab + ipilimumab as neoadjuvant therapy for patients with HCC; To evaluate the safety profile in patients with HCC who receive neoadjuvant nivolumab + ipilimumab treatment; To collect HCC tumor tissue and peripheral …

  • 27 Jan, 2021
  • 8 locations
Intraoperative Endoscopic Ultrasound for Pancreatic Cancer (EchoSurg)

Nowadays pancreatic cancer is one of the deadliest oncological pathologies. The only effective curative tool is the surgery. Before the intervention, an endoscopic ultrasound is performed on the patient to carry out the biopsy of the main tumor. In this study, the echoendoscopie will be extended to lymph node staging …

pancreatic neoplasm
endoscopic ultrasound
  • 20 Apr, 2022
  • 1 location
Molecular Profiling of Exosomes in Tumor-draining Vein of Early-staged Lung Cancer

This is an observational prospective single-center study of 30 patients operated for early-staged non-small cell lung cancer. The main aim is the analysis of molecular profiling of exosome with a sample in tumor-draining vein in order to identify prognostic molecular characteristics associated with cancer recurrence after surgery.

lung carcinoma
lung cancer
  • 20 Nov, 2021
  • 1 location
A Study of Combination Spartalizumab and Canakinumab in Patients With Localized Clear Cell Renal Cell Carcinoma (SPARC-1)

Primary Objective: To confirm the safety and feasibility of canakinumab and spartalizumab (PDR-001) administered using a standard dose / schedule in the neo-adjuvant setting in renal cell carcinoma Secondary Objectives: To assess the immune response to combination canakinumab and spartalizumab To assess anti-tumor activity as measured by pathologic downstaging

neutrophil count
clear cell renal cell carcinoma
  • 25 May, 2022
Perioperative FLOT vs Adjuvant XELOX for CA Stomach

This is a single centre randomised controlled trial, comparing perioperative FLOT versus adjuvant XELOX for locally advanced gastric and esophagogastric junction cancers. Patients with operable clinical T3 or above and N1 or above gastric and esophagastric junction cancer would be recruited. Participants would be randomised to perioperative FLOT versus adjuvant …

  • 13 Apr, 2022
  • 1 location
Calcium Channel Blockade in Primary Aldosteronism

Primary aldosteronism is a common cause of hypertension. Recent evidence suggests that many patients with bilateral idiopathic hyperaldosteronism harbor gain-of-function somatic mutations in zona glomerulosa calcium channels that results in aldosterone production. This finding raises the possibility that calcium channel antagonists may be a targeted therapy to reduce aldosterone production …

adrenal venous sampling
calcium channel
  • 16 Dec, 2021
  • 1 location
Unintentional Weight Loss After Oesophagectomy (UWL)

The incidence of cancer of the oesophagus is increasing. While surgical removal of the tumour (oesophagectomy) may offer the best chance of cure, such major operations are associated with long-term complications such as poor appetite, unintentional weight loss and nutritional impairments. In the long-term, unintentional weight loss of 10-30% increases …

Accepts healthy volunteers
  • 05 May, 2022
  • 1 location
Long-term Enlarged Survival After an Enhanced Recovery Protocol (LESAS). (LESAS)

The main objective of this study is to analyze the impact on three years survival of an enhanced recovery program (PRI) after radical surgery for colorectal cancer. As secondary objectives, we propose to analyze the weight of each of the predefined items in the oncological results as well as the …

  • 22 Mar, 2022
  • 10 locations