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Found 679 clinical trials
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Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial

Concussion is defined as any temporary disturbance in brain function following a blow to the head. It may not involve a loss of consciousness and usually results in a post concussive headache (PCH) immediately after the injury. Between 30 and 50 percent of patients with concussion will develop postconcussive syndrome …

headache
metoclopramide
confusion
amnesia
  • 22 views
  • 07 Nov, 2020
  • 1 location
None
Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer

Women with BRCA germline mutations face a very high risk of developing breast cancer during their lives. It was shown that for carrier patients, breast conservation, comprising of lumpectomy followed by whole breast radiation, was not associated with increased risk of ipsilateral breast cancer recurrence as compared with non carriers …

hormone therapy
mastectomy
adjuvant therapy
adjuvant chemotherapy
lumpectomy
  • 6 views
  • 07 Nov, 2020
  • 1 location
None
Efficacy and Safety of Cetuximab in Combination With Cisplatin Gemcitabine as First-Line Therapy in Advanced NSCLC

Lung cancer is the leading cause of cancer deaths worldwide. It is estimated that, in 2004, 173,700 new cases of lung cancer will be diagnosed in the United States alone and 164,440 deaths due to this disease will occur(13) . NSCLC accounts for approximately 80% of all lung cancers. Among …

stage iv non-small cell lung cancer
metastasis
platinum-based chemotherapy
gemcitabine
neutrophil count
  • 3 views
  • 07 Nov, 2020
  • 1 location
None
Positioning Imatinib for Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH) is a rare condition in which a narrowing of blood vessels carrying blood through the lungs puts an increased work load on the heart; it has to work harder to pump blood through the lungs. While current treatments relieve some of the symptoms, they do not …

  • 0 views
  • 27 Sep, 2021
  • 8 locations
None
Adjustable Gravitational vs. Adjustable Differential Pressure Valves in iNPH

The goal of the study is to verify theoretical benefit of ventriculoperitoneal shunting with MIETHKE M.blue valve in patients with iNPH. The study is designed to assess walking and balance, urinary function, cognitive performance and quality of life before and after shunting and compare the results between the patients with …

  • 0 views
  • 25 Jan, 2021
  • 1 location
None
PEEP Mask for Tracheobronchomalacia-Induced Cough

This study aims to determine if an expiratory resistance device that delivers non-invasive positive expiratory pressure (nPEP) will reduce or stop coughing, reduce airway resistance and improve quality of life in patients with tracheobronchomalacia (TBM) who are not candidates for tracheal stenting.

  • 0 views
  • 19 Sep, 2021
  • 1 location
None
Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion

This is a proof-of-concept phase IIB, double-blind, randomized, placebo-controlled trial to evaluate the safety and efficacy of 40 mg atorvastatin to reduce persistent lung inflammation after successful TB treatment completion in HIV-infected and HIV-uninfected adults measured by PET/CT.

  • 0 views
  • 27 Jan, 2021
  • 1 location
None
Study of Atezolizumab Combined With Split-dose Gemcitabine Plus Cisplatin in Urothelial Carcinoma

Phase II, multicenter, non-randomized, single-arm, open-label trial of atezolizumab in combination of split-doses of gemcitabine plus cisplatin in patients with locally advanced or metastatic urothelial carcinoma. The Aurea trial aims to evaluate the preliminary efficacy of atezolizumab plus split-dose gemcitabine and cisplatin (GC) for the first-line setting, in patients with …

  • 0 views
  • 29 Sep, 2021
  • 12 locations
None
Enhanced Bioscaffold for Volumetric Muscle Loss

This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.

  • 0 views
  • 27 Jan, 2021
  • 1 location
None
The FDR (Femoral Derotaton) Trail.

Femoral derotational osteotomy is the gold standard to correct symptomatic patients with increased femoral AV. There is no clear evidence in the literature supporting which surgical technique or implant that should be used. Traditionally these patients are treated with an open osteotomy and plate and screw fixation. In recent years …

  • 0 views
  • 11 Feb, 2021
  • 1 location