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Found 679 clinical trials
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Optimization of VIM Targeting in Essential Tremor Surgery

Deep brain stimulation (DBS) for essential tremor is based on the intermedius ventralis nucleus of the thalamus (VIM) stimulation. This structure is however very difficult to target, as it remains invisible on imaging. The current procedure based on awake surgery with clinical and electrophysiological testings has several limitations that lead …

  • 0 views
  • 01 Feb, 2021
  • 2 locations
None
CyberKnife Stereotactic Radiosurgery for Low and Intermediate Risk Prostate Cancer

The purpose of this study is to determine the side effects and how effective CyberKnife stereotactic ablative body radiation (SABR) is in patients with prostate cancer. The CyberKnife system is a new type of radiation machine that uses a special system to precisely focus large doses of x-rays on the …

hormone therapy
prostatectomy
metastasis
adenocarcinoma of prostate
bone scan
  • 26 views
  • 08 Nov, 2020
  • 1 location
None
Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer

Women with BRCA germline mutations face a very high risk of developing breast cancer during their lives. It was shown that for carrier patients, breast conservation, comprising of lumpectomy followed by whole breast radiation, was not associated with increased risk of ipsilateral breast cancer recurrence as compared with non carriers …

adjuvant chemotherapy
immunostimulant
endocrine therapy
hormone therapy
mastectomy
  • 6 views
  • 07 Nov, 2020
  • 1 location
None
Efficacy and Safety of Cetuximab in Combination With Cisplatin Gemcitabine as First-Line Therapy in Advanced NSCLC

Lung cancer is the leading cause of cancer deaths worldwide. It is estimated that, in 2004, 173,700 new cases of lung cancer will be diagnosed in the United States alone and 164,440 deaths due to this disease will occur(13) . NSCLC accounts for approximately 80% of all lung cancers. Among …

platinum-based chemotherapy
neutrophil count
ct scan
metastasis
cetuximab
  • 3 views
  • 07 Nov, 2020
  • 1 location
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Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial

Concussion is defined as any temporary disturbance in brain function following a blow to the head. It may not involve a loss of consciousness and usually results in a post concussive headache (PCH) immediately after the injury. Between 30 and 50 percent of patients with concussion will develop postconcussive syndrome …

metoclopramide
confusion
headache
amnesia
  • 22 views
  • 07 Nov, 2020
  • 1 location
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Positioning Imatinib for Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH) is a rare condition in which a narrowing of blood vessels carrying blood through the lungs puts an increased work load on the heart; it has to work harder to pump blood through the lungs. While current treatments relieve some of the symptoms, they do not …

  • 0 views
  • 27 Sep, 2021
  • 8 locations
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Bilateral Percutaneous Nephrolithomy

The purpose of this study is to determine the effective regimen for definitive surgical therapy of bilateral kidney stones. It is unknown whether patients who undergo simultaneous bilateral percutaneous nephrolithotomy (PCNL) experience improved post-operative outcomes compared to patients who have staged unilateral procedures.

  • 0 views
  • 07 May, 2021
  • 1 location
None
Proton or Photon RT for Retroperitoneal Sarcomas

This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for further studies. "Investigational" means that the intervention is still being studied and that …

  • 4 views
  • 25 Jan, 2021
  • 10 locations
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PET/CT Guided Antifungal Stewardship in Invasive Pulmonary Aspergillosis

OPTIFIL is a pilot prospective multicenter study based over the hypothesis that the normalization of the functional imaging 18F-FDG-PET/CT during the Invasive pulmonary aspergillosis (IPA) could occur earlier than that of conventional imaging. This study evaluates the therapeutic response through a systematic 18F-FDG-PET/CT at week 6. The latter response will …

  • 31 views
  • 27 Jan, 2021
  • 1 location
None
Combined Air-plasma Flow and Nitric Oxide Therapy in Cardiac Surgery

In cardiovascular surgery, the most common and serious complication is postoperative wound infection. The most formidable wound complication is mediastinitis, the frequency of which varies from 1 to 3%. Currently, mortality in this group of patients varies from 3.5 to 58.3%. In this regard, the relevance of developing new methods …

  • 0 views
  • 26 Jan, 2021
  • 1 location