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Found 329 clinical trials
Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations

Background PIDD stands for primary immune dysregulation. It is a general term that includes many different inherited immune system disorders. The immune system is the part of the body that helps fight disease and infection. People with PIDDs can develop many kinds of health problems. One of these is inflammatory …

diarrhea
immune disorder
enteropathy
urine tests
immunodeficiency
  • 13 views
  • 15 Mar, 2021
  • 1 location
Effect of Pelvic Radiotherapy on the Intestinal Microbiome and Metabolome

Eight in ten patients will develop bowel problems during radiotherapy, eg diarrhoea, pain and incontinence, half will develop difficult long-term bowel problems. It is not known why some people get bowel problems and others do not and there is no test to predict who will develop bowel problems following their …

cancer
bladder tumor
  • 0 views
  • 16 Aug, 2021
  • 1 location
Microbiomes of Pelvic Pain

This research study seeks to provide more insight as to how the microbiome affects or is affected by conditions causing chronic pelvic pain such as Interstitial Cystitis (IC), Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS), Lower Urinary Tract Symptoms (LUTS), or Overactive bladder (OAB). Depression and many chronic pain disorders are …

depression
lower urinary tract symptoms
prostatitis
cystitis
pain disorders
  • 741 views
  • 13 Jun, 2021
  • 1 location
Individualization Treatment Through a Self-managed Web-based Solution in Ulcerative Colitis

This study investigates the effect of individualized monotherapy with Mesalazine (Pentasa Sachet ) on time to remission in patients with mild to moderate UC in an eHealth setting.

colitis
hematochezia
pentasa
remission
ulcerative colitis
  • 10 views
  • 25 Jan, 2021
  • 1 location
Identification Genetic Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease

To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of HD. The newly formed HAEC Collaborative Research Group (HCRG) will utilize the 4 participating centers in the current consortia …

  • 73 views
  • 21 Jan, 2021
  • 1 location
Brain Activity and Oxygenation Inflammatory Bowel Disease (IBD) Patients

Symptoms such as fatigue, sleep disturbances, anxiety and depression are common in patients with IBD, but the cause is unknown. Understanding how these behaviors occur in IBD and their role in symptoms may help improve management of IBD. How IBD leads to changes in brain function remains unclear. Inflammation and …

  • 0 views
  • 10 May, 2021
  • 1 location
Risk of Hepatitis Flare in Patients With Previous Hepatitis B Virus Exposure Amongst Patients

The purpose of this study is to study the risk of hepatitis flare in patients with previous hepatitis B virus exposure amongst patients on immunosuppressive and biological modifier therapies

immunosuppressive agents
  • 0 views
  • 11 Aug, 2021
  • 1 location
Sonographic Assessment in Severe Ulcerative Colitis Patients Admitted for Intravenous Corticosteroids and Eligible for Infliximab Rescue Therapy; a Prospective Clinician-blinded Observational Study Protocol.

Introduction Acute severe ulcerative colitis (ASUC) occurs in 15-25 % of all ulcerative colitis (UC) patients. Initial treatment with intravenous corticosteroids fails in 30-50 % of patients, for whom the next line of treatment is biological therapy or colectomy. Acute colectomy has a higher risk of morbidity and mortality than …

colectomy
infliximab
remission
corticosteroids
endoscopy
  • 0 views
  • 03 Feb, 2021
  • 1 location
Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound

Rationale Ulcerative colitis (UC) is remitting disease with a variable course. Predicting disease relapse after remission is important for the adjustment of medical treatment. Ileocolonoscopy is the best tool for doing this, but due to its invasiveness should be replaced by a method better accepted by the patient. Gastrointestinal ultrasound …

  • 17 views
  • 24 Jan, 2021
  • 3 locations