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Found 57 clinical trials
Safety and Efficacy of Allogeneic Adipose Tissue Mesenchymal Stem Cells in Diabetic Patients With Critical Limb Ischemia

Phase II national, multicenter, double-blind, randomized, placebo-controlled, phase-3 clinical trial of 3 parallel groups.

diabetes
ischemia
limb ischemia
revascularisation
  • 0 views
  • 23 Jul, 2022
  • 9 locations
Efficacy and Safety Comparison of the Open and Endovascular Surgical Methods for the Treatment of Long Atherosclerotic Lesions of the Femoral-popliteal Segment Below the Knee TASC D in Patients With Critical Limb Ischemia

This is prospective, randomized study. The main objective of the study is to compare the clinical efficacy and safety of two therapies for the treatment of prolonged atherosclerotic lesions of the arteries of the femoropopliteal segment below the knee, TASC II type D - femoropopliteal distal bypass with a synthetic …

  • 1 views
  • 25 Jan, 2021
  • 1 location
Treatment of No-option CLI by G-CSF-mobilized PB-MNC

This study will investigate the efficacy of G-CSF mobilized mononuclear cell injection of patients with PAD who presented with no-option CLI. Forty no-option CLI patients who presented with rest pain, non-healing ischemic ulcer or gangrene will be randomized into 2 groups. The control group will be treated by medication and …

rest pain
granulocyte colony stimulating factor
gangrene
ischemic ulcer
  • 3 views
  • 14 Feb, 2022
  • 1 location
Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA) (MarrowCHAMP)

Patients scheduled for major extremity lower amputation to receive bone marrow cells (cBMA) injected IM in the leg proximal to the amputation in the index limb to prevent ischemic wound complications after surgery.

gangrene
  • 3 views
  • 26 Feb, 2022
  • 1 location
A Study of the TEmporary Spur StEnt System for the Treatment of Lesions Located in the InfraPoplitEal ARteries Using a LIMUS-base DCB

This is a non-randomized, prospective, single center pilot study designed to evaluate the safety of the Temporary Spur Stent System to treat patients with infrapopliteal arterial disease, when used in conjunction with a commercially available limus-base drug coated balloon.

ischemia
intermittent claudication
stenotic
duplex ultrasound
intravascular ultrasound
  • 0 views
  • 22 Feb, 2021
  • 1 location
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

The aim of this clinical study is to assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in diabetic patients with peripheral arterial disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging …

obstructive disease
computed tomography angiography
vascular disease
angiography
arteriopathy
  • 10 views
  • 12 Feb, 2022
  • 1 location
Temsirolimus Alone or Paired With Dexamethasone Delivered to the Adventitia to eNhance Clinical Efficacy After Femoropopliteal Revascularization (TAP-DANCE)

, after revascularization of femoropopliteal lesions in symptomatic patients with moderate to severe claudication (Rutherford 2-3) or critical limb ischemia (CLI) with rest pain (Rutherford 4). Subjects

ischemia
critical limb ischaemia
aspirin
balloon angioplasty
limb ischemia
  • 8 views
  • 26 Feb, 2022
  • 8 locations
Additional Hyperbaric Oxygen After Lower Extremity Amputation (AHOLEA)

This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or control group.

amputation of the lower limb
osteomyelitis
ischemia
hyperbaric oxygen
lower extremity amputation
  • 93 views
  • 05 Mar, 2022
  • 2 locations
Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With LEAD (IRONPAD) (IRONPAD)

Introduction: Anaemia due to iron and vitamin deficiency among patients with critical limb ischemia is high (>50%). The prevalence of a higher rate of anaemia extends into the three months

  • 0 views
  • 20 Jun, 2022
  • 1 location
Hepatocyte Growth Factor to Improve Functioning in PAD (HI-PAD)

HI-PAD is a placebo controlled double-blind randomized pilot clinical trial to determine whether VM202 may improve walking ability in people with lower extremity peripheral artery disease (PAD).

arteriopathy
peripheral arterial diseases
  • 7 views
  • 18 May, 2022
  • 1 location