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Found 313 clinical trials
Rapid Normalization of Vitamin D Deficiency in PICU

normalization of vitamin D deficiency improves survival and health-related quality of life following critical illness. The VITdALIZE-KIDS trial is a multicentre randomized clinical trial in Canadian Pediatric

cholecalciferol
malnutrition
calcium
vitamins
  • 22 views
  • 03 Mar, 2021
  • 9 locations
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.

nephro-protective effects are preserved in critical illness. Cardiac surgery appears to be the best setting to test the likely beneficial renal effects of amino acid because of pathophysiological

critical illness
kidney injury
hypoperfusion
continuous infusion
acute renal failure
  • 1 views
  • 29 Jan, 2021
  • 1 location
Investigation of Sleep in the Intensive Care Unit

Sleep deprivation is common and severe in critically ill patients cared for in intensive care units (ICUs), and is hypothesized to be a key modifiable risk factor for delirium and long-term cognitive disability. Dexmedetomidine reduces the incidence of delirium in ICU patients by unknown mechanisms. This project will determine whether …

critical illness
mechanical ventilation
dexmedetomidine
  • 7 views
  • 24 Jan, 2021
Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients

Hyperglycemia is a common condition among hospitalized patients. The occurrence of severe hyperglycemia is associated with increased morbidity and mortality in several populations. Several trials assessed the benefits of aggressive versus conventional glucose control. These studies evaluated different patient populations, glucose targets and treatment protocols and as a result reported …

diabetes mellitus
insulin
type 2 diabetes mellitus
hypoglycemia
hyperglycemia
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Facilitating Communication Study

This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their families to secure care in line with patients' goals of care over an illness trajectory, …

diabetes
congestive heart failure
stroke
traumatic brain injury
esrd
  • 269 views
  • 26 Jan, 2021
  • 5 locations
Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation

The aim of this study is to evaluate the effect of early activity and mobilisation during prolonged IMV on the composite outcome "days alive and out of hospital to day 180". The effect of the intervention on mortality, physical, cognitive and psychological function at 180 days, as well as cost-effectiveness …

  • 1116 views
  • 26 Jan, 2021
  • 51 locations
Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial

This is a multicenter, open-label, 2x2 factorial, randomized-controlled trial in critically-ill patients with novel coronavirus disease 2019 (COVID-19) evaluating the efficacy and safety of full-dose vs. standard prophylactic dose anticoagulation and of antiplatelet vs. no antiplatelet therapy for prevention of venous and arterial thrombotic events.

SARS
blood clot
anticoagulation therapy
covid-19
acute infection
  • 50 views
  • 24 Jan, 2021
  • 1 location
Early Versus Differed Arterial Catheterization in Critically Ill Patients With Acute Circulatory Failure:

The objective of the present research is a combination of a one-sided test of non-inferiority and a one-sided test of superiority. A stepped approach will be used to evaluate these hypotheses a less invasive intervention (i.e., no indwelling arterial catheter insertion until felt absolutely needed, according to consensual and predefined …

critical illness
hypoperfusion
lactic acid
norepinephrine
systolic blood pressure
  • 35 views
  • 23 Jan, 2021
  • 10 locations
Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients

Primary purpose : mortality at Day 28 Secondary purposes : Daily SOFA (Sequential Organ Failure Assessment) score lessening within Intensive Care Unit (ICU) Duration of increasing doses of norepinephrine infusion to maintain target mean arterial pressure Number of care-related infections within ICU

critical illness
shock
plasma albumin
norepinephrine
organ failure
  • 44 views
  • 23 Jan, 2021
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.

This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is …

norepinephrine
edema
furosemide
  • 0 views
  • 25 Jan, 2021
  • 8 locations