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Found 315 clinical trials
The Effect of Higher Protein Dosing in Critically Ill Patients

The investigator will investigate the effects of higher protein/amino acid dosing (2.2 g/kg/d) vs usual protein/amino acid dosing (1.2 g/kg/d) on clinical outcomes in nutritionally high risk ill patients.

severe malnutrition
amino acids
  • 26 Jan, 2021
  • 36 locations
Brief Intervention for ICU Patients With Alcohol Use Disorders

Patients non-electively admitted to intensive care units (ICUs) will be screened for eligibility. The investigators will include adult patients with risk level alcohol use, defined by AUDIT-C score (>5 for females, >6 for males). Informed consent will be obtained from the patient in the end or shortly after the ICU …

  • 23 Jan, 2021
  • 3 locations
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients. Investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy.

  • 07 Mar, 2021
  • 8 locations
Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function

Each year, only one third of patients registered on the waiting list receive a kidney transplant. Numerous paths are being explored with the aim of reversing this shortage. The first is to increase the number of organs by developing harvesting from donors in a state of brain-death (BD) termed "expanded …

induced hypothermia
circulatory arrest
kidney transplant
therapeutic hypothermia
  • 26 Jan, 2021
  • 73 locations
Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock

illnesses. Recent data challenge the wisdom of providing standard amounts of calories and protein during the acute phase of critical illness. Studies designed to improve enteral nutrition delivery showed no

  • 23 Jan, 2021
  • 51 locations
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients

Introduction- Hospital acquired infections (HAI) are a major cause of morbidity and mortality and increase health care costs. Critically ill patients are particularly susceptible to these infections and have an even higher mortality. One intervention that has gained much interest in the medical literature for reducing infection rates and deaths …

critical illness
mechanical ventilation
nosocomial infections
antibiotic therapy
  • 28 Jan, 2021
  • 3 locations
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

The World Health Organization, U.S. Centers for Disease Control and Prevention, Association of Medical Microbiology and Infectious Diseases (AMMI) Canada, and Health Canada have all declared antimicrobial resistance a global threat to health, based on rapidly increasing resistance rates and declining new drug development. Up to 30-50% of antibiotic use …

antimicrobial agent
antibiotic therapy
blood culture
  • 27 Jan, 2021
  • 58 locations
Randomized Embedded Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

treatment modalities in the event of a respiratory pandemic resulting in critical illness. REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19.

  • 26 Jan, 2021
  • 108 locations
COVID-19 Antithrombotic Rivaroxaban Evaluation

, such as through severe illness and hypoxia, may predispose patients to thrombotic events. The severe inflammatory response, critical illness, and underlying traditional risk factors may all predispose

  • 08 Mar, 2021
  • 36 locations
Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan on Outcomes of Coronavirus Infection?

controlled trials (RCTs) of vaccines and novel antivirals to address SARS-CoV-2 directly. However, the critical illness complications of COVID-19 are caused in part by SARS-CoV-2's binding and inhibiting

  • 25 Jan, 2021
  • 18 locations