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Found 306 clinical trials
The Frequency of Screening and SBT Technique Trial: The FAST Trial

Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing. When patients start to get better, they gradually do more of the breathing and the machine does less-this is called weaning. Although ventilator use saves lives, the longer it is used, …

  • 22 Jan, 2021
  • 12 locations
PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children

Recent decreases in Pediatric Intensive Care Unit (PICU) mortality rates have been offset by increased morbidity and length of stay for vulnerable young patients. Heavy sedation, bedrest, and delirium contribute to a PICU culture of immobility. While studies in adult ICU patients demonstrate the clinical benefits of early mobilization, fewer …

  • 24 Feb, 2021
  • 1 location
Pulse Oxygen Saturation (SpO2) Directed Oxygen Therapy

Investigators hypothesized that a relative low SpO2 directed oxygen therapy would reduced the mortality in patients staying longer than 72 hours in ICUs.

  • 22 Jan, 2021
  • 17 locations
Early Versus Late Parenteral Nutrition in the Pediatric Intensive Care Unit

In the PEPaNIC trial it is investigated whether withholding parenteral nutrition during the first week in critically ill children is beneficial, compared to the current standard of the early start of parenteral nutrition.

  • 22 Jan, 2021
  • 2 locations
Bolus Versus Continuous Infusion of Meropenem

This study arises from the need to optimize antibacterial drug usage to face increasing drug resistance among gram-negative pathogens in intensive care units. Gram-negative organisms are responsible for 70% of drug-resistant infections acquired in the intensive care unit. Meropenem is a -lactam, carbapenem, antibacterial agent usually administered by intermittent infusion. …

  • 27 Jan, 2021
  • 12 locations
Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

For adult patients with acute respiratory failure requiring invasive mechanical ventilation, does a ventilation strategy using proportional assist ventilation with load-adjustable gain factors (PAV+) result in a shorter duration of time spent on mechanical ventilation than a ventilation strategy using pressure support ventilation (PSV)?

pressure support
mechanical ventilation
  • 24 Jan, 2021
  • 24 locations
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients

In the VITdAL-ICU trial using a large oral dose of vitamin D3 in 480 adult critically ill patients, there was no benefit regarding the primary endpoint hospital length of stay. However, the predefined subgroup with severe vitamin D deficiency (25(OH)D 12ng/ml) had significantly lower 28-day mortality (36.3% placebo vs. 20.4% …

  • 27 Jan, 2021
  • 26 locations
Conservative Versus Conventional Oxygen Administration in Critically Ill Patients

Oxygen supplementation in the inspired mixture is commonly used in critically ill patients and observational studies highlight that those patients remain hyperoxemic for substantial periods during Intensive Care Unit stay. However, exposure to inhaled oxygen-enriched mixtures is widely recognized as potentially harmful and cause of organ damage. Although, the specific …

critical illness
oxygen saturation
mechanical ventilation
  • 24 Jan, 2021
  • 1 location
Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients

Critically ill patients usually develop hyperglycemia, which is associated with an increased risk of morbidity and mortality. Controversy exists on whether targeting normal blood glucose concentrations with insulin therapy, referred to as tight blood glucose control (TGC) improves outcome of these patients, as compared to tolerating hyperglycemia. It remains unknown …

critical illness
enteral nutrition
  • 28 Jan, 2021
  • 5 locations
The Effect of Higher Protein Dosing in Critically Ill Patients

The investigator will investigate the effects of higher protein/amino acid dosing (2.2 g/kg/d) vs usual protein/amino acid dosing (1.2 g/kg/d) on clinical outcomes in nutritionally high risk ill patients.

severe malnutrition
amino acids
  • 26 Jan, 2021
  • 36 locations