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Found 311 clinical trials
Hydrocortisone and Fludrocortisone for Critical Illness-related Corticosteroid Insufficiency (HORNbILL)

The study aims at assessing the efficacy and the safety of hydrocortisone combined with fludrocortisone compared to placebo in ICU adults with critical illness related corticosteroid

  • 21 Mar, 2022
MONITOR-IC Post ICU Care Study (MiCare)

OBJECTIVE To evaluate the clinical effectiveness and cost effectiveness of structured, multidisciplinary and personalized post-ICU care versus usual care on physical and psychological functioning, and quality of life (QoL) of ICU survivors one and two years post-ICU. RESEARCH QUESTION What is the clinical- and cost effectiveness of structured, personalized post-ICU …

Accepts healthy volunteers
  • 14 May, 2022
  • 1 location
Randomized Trial of Sedative Choice for Intubation (RSI)

Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains …

  • 10 May, 2022
  • 1 location
On the Road to Recovery After Critical Illness

Spending time on intensive care can affect people in many different ways. Ability to move, walk, concentrate and remember events can all be affected. People may find their mood is altered and anxiety, stress and reduced confidence are common. These symptoms are frequently grouped together in a term called 'post …

  • 15 Jun, 2021
  • 1 location
Digital Rehabilitation Environment Augmenting Medical System (DREAMS)

D.R.E.A.M.S. will assess an immersive digital reality-augmenting system in reducing the occurrence of cognitive, behavioral, and emotional consequences of critical illness and environmental

critical illness
  • 05 Mar, 2022
  • 1 location
Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis (GRAIL^3)

. Our hypothesis is that IV ganciclovir administered early in critical illness will effectively suppress CMV reactivation in CMV seropositive adults with sepsis-associated acute respiratory failure

  • 17 Jun, 2022
  • 17 locations
Diaphragm Dysfunction During Prolonged Mechanical Ventilation (DD-SRPR)

increases the economic burden of critical illness. Ventilator-dependence results from an imbalance between the load and capacity of the respiratory muscle pump. Patients who fail a trial of spontaneous

  • 05 Feb, 2022
  • 1 location
Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock. (COCCA)

The purpose of this randomized controlled trial is to evaluate the hemodynamic effect of low dose corticosteroid therapy (hydrocortisone and fludrocortisone) in the treatment of adult cardiogenic shock.

pulmonary congestion
ejection fraction
  • 30 Jun, 2022
  • 12 locations
Web-based Follow-up to Former ICU Patients (WIVA)

This study evaluates if a web-based 1-year programme is a useful method for follow-up intensive care survivors with short ICU-stay. Half of the participants are randomized into receiving the web-based follow-up while the other half will receive no follow-up.

  • 02 Mar, 2022
  • 1 location
Ultrasound and MRI Measurement of Quadriceps Femoris Muscle in Critically Ill Children (Echo-QF-IRM)

A vast majority of children admitted to paediatric intensive care (PICU) present with faltering growth during their admission. Muscle mass loss is an early, intense and frequent phenomenon in this setting, which is associated with impaired outcomes. Recent international guidelines recommend monitoring both nutritional status and muscle mass throughout hospital …

  • 13 Mar, 2022