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Found 46 clinical trials
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Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

Background: People are living longer and are more likely to survive a heart attack if they have one. Longer life expectancy is good but it also means more people get chronic heart failure over time. This is a condition in which the heart doesn't pump blood as well as it …

heart failure
cardiopulmonary exercise testing
chronic heart failure
radionuclide ventriculography
systolic heart failure
  • 09 Apr, 2019
  • 1 location
Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 2B Study (VIPAH-PRN 2B)

The objectives of this study are to evaluate the effects of RT234 on exercise parameters assessed by a specialized exercise test (Cardiopulmonary Exercise Test or CPET) in patients with

forced expiratory volume
connective tissue disease
right heart catheterization
overlap syndrome
  • 07 Oct, 2022
  • 14 locations
Exploratory Ph 2A, Double-Blind, Placebo-Controlled Dose Escalation Study of Safety, Tolerability, PD, & PK of HU6 for Subjects With Obese HFpEF (HFpEF)

This is a Phase 2A, randomized, parallel-group, placebo-controlled, double-blind, within subject dose escalation trial with 3 dose levels of HU6 and placebo. Subjects will be randomized (1:1) either to HU6 or placebo. Two dose levels will be administered in sequential order (150 mg daily followed by 300 mg daily), each …

  • 08 Apr, 2023
  • 8 locations
Benefits of Ketogenic Diet in Patients With Heart Failure With Preserved Ejection Fraction: A Pilot Study

This study is being done to evaluate the effects of a low carbohydrate ketogenic diet on exercise tolerance in patients with Heart Failure with Preserved Ejection Fraction (HFpEF), also known as Diastolic Heart Failure (DHF).

body mass index
medical therapy
diastolic heart failure
  • 23 Oct, 2022
  • 1 location
The Effect Custom Foot Orthotics on Comfort, Kinetics and Kinematics

The overarching aim of this project is to investigate the role of custom foot orthotics in a 'return to performance' framework as the ultimate part of the 'return to sport continuum'. The aim of this particular study is to investigate the effect of Custom Foot Orthotics (CFO) made from different …

Accepts healthy volunteers
  • 13 Jun, 2022
  • 1 location
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

exercise stress test
cardiopulmonary exercise testing
endothelin receptor antagonist
  • 04 Oct, 2022
  • 36 locations
Exercise Testing in Diseases and Health

Cardiopulmonary exercise test (CPET) is a helpful tool for evaluation of aerobic exercise capacity and tolerance for variety of population. CPET provides a full assessment of the physiologic

Accepts healthy volunteers
  • 13 Apr, 2022
  • 1 location
Post Cardiac Valvular Surgery Rehabilitation (PORT)

The incidence of adult rheumatic valvular heart disease is 2.34% to 2.72% in China. Although guidelines or consensus recommendations recommend rehabilitation after valve surgery, clinical studies are still lacking, especially for Chinese patients. Current limited clinical studies focus mainly on physical capacity and self-assessed mental health. The investigators hope to …

educational intervention
walk test
rheumatic heart disease
exercise test
heart disease
  • 15 Feb, 2022
  • 1 location
Effects of Comprehensive Postoperative Pulmonary Tele-Rehabilitation in Elderly Patients With Resectable Lung Cancer

The purpose of this study is to confirm the effectiveness of a mobile messenger-based home tele-rehabilitation protocol in patients who have undergone lung resection surgery. By analyzing the difference from the existing postoperative pulmonary rehabilitation, the investigators would like to propose a new pulmonary tele-rehabilitation protocol.

lung carcinoma
  • 07 Oct, 2022
  • 1 location
Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).

cardiopulmonary exercise test (CPET). Twenty patients with diagnosed IPF with mild (or absent) mechanical restriction and 20 healthy ageand sex-matched controls will be recruited from a database of volunteers

nitric oxide
Accepts healthy volunteers
cardiopulmonary exercise testing
interstitial lung disease
  • 06 May, 2022
  • 1 location