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Found 385 clinical trials
Phenotyping Disease Severity in Asthma

severity and healthy control subjects, to examine differences in the response to corticosteroids (CS) in vitro. These studies will test whether intrinsic differences exist between the responses to ICS in

  • 0 views
  • 09 Jun, 2022
  • 1 location
Long Term Follow up of Children Enrolled in the REDvent Study

children with likely sustained effects on lung repair and muscle strength. Moreover, common medication choices (i.e. neuromuscular blockade, corticosteroids) or other complications in the ICU (i.e

pneumonia
ventilator-induced lung injury
acute respiratory distress syndrome
oxygenation index
delirium
  • 15 views
  • 15 Feb, 2022
  • 1 location
Diabetes Screening in Patients on Long-Term Glucocorticoid Therapy (DIACORT)

(leukaemia, lymphoma, myeloma, etc.). They have many side effects, including effects on carbohydrate metabolism. Corticosteroids are diabetogenic because they disrupt pancreatic insulin secretion and

glycosylated hemoglobin
kidney transplant
insulin
hypoglycemic agents
fasting
  • 2 views
  • 22 Mar, 2022
  • 1 location
Predictive Immune Biomarkers of COVID-19 Pathogenesis to Influence Therapeutic Management (IMMUNOMARKCOV)

using corticosteroids or biotherapies targeting IL-6 may be valuable in some patients. Based on a better understanding of COVID-19 immunopathogenesis, the identification of predictive biomarkers early

  • 0 views
  • 05 Apr, 2022
  • 2 locations
Monocytic Expression of HLA-DR After Liver Transplantation (EdMonHG)

-transplant immune response. Some treatments, such as corticosteroids, which are widely used for the induction of post-transplant immunosuppression, may affect the innate immune response. However, it has been

cirrhosis
acute on chronic liver failure
antibiotics
shock
immunosuppression
  • 2 views
  • 16 Feb, 2022
  • 1 location
Lysosomal Acid Lipase Activity in Nonalcoholic Fatty Liver Disease (NAFLD LAL)

wild type allele. The following exclusion criteria will be considered: any type of malignant disease in the past 5 years, any type of inflammatory or autoimmune disease, corticosteroids for

  • 0 views
  • 09 Jul, 2022
  • 1 location
Comparative Analysis of the Th17 Cellular Response in Active and Inactive Pemphigus Vulgaris Patients

This study will compare the pattern of Th17 immune response in active and inactive pemphigus subjects. Skin and serum samples will be taken at the moment of enrollment.

  • 0 views
  • 03 Sep, 2021
  • 3 locations
Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome (LEOPARDS)

The overall goal of the study is to risk stratify pediatric Acute Respiratory Distress Syndrome (ARDS) patients and to identify sub-phenotypes with shared biology in order to appropriately target therapies in future trials. This is a prospective, multicenter study of 500 intubated children with ARDS, with planned blood collection within …

assisted ventilation
oximetry
respiratory failure
assisted breathing
acute respiratory distress
  • 3 views
  • 10 Mar, 2022
  • 16 locations
Dynamics of Markers of Infection and Inflammation in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients

Patients requiring admission to the hospital due to a moderate and severe COVID-19 infection may differ in their ability to respond to viral infection and to eliminate viral load. Several comorbidities and interventions like antivirotic or antiinflammatory treatment may also modify expected patients response and decrease of viral load. In …

  • 0 views
  • 17 Oct, 2021
  • 1 location
Evaluate the Therapeutic Effect of Inhaled Corticosteroid in Asthmatic Children

Inhaled corticosteroid (ICS) is considered the first line medication for asthma, however, the therapeutic effect is markedly different even in patients with almost similar clinical manifestations. Our study was designed to explore the clinical and genetic factors that may influence the effectiveness of ICS in asthmatic children.

budesonide
corticosteroids
  • 0 views
  • 03 Mar, 2022
  • 1 location