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Found 254 clinical trials
Prognostic Factors in Zygapophyseal Osteoarthritis Infiltration: a Prospective Cohort Study

Magnet Resonance Image findings of facet osteoarthritis and patient characteristics are prognostic factors for improving or worsening the clinical outcome after treatment with facet infiltration.

  • 20 Apr, 2022
  • 3 locations
The CHRONICLE Study: A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals With Severe Asthma in the United States

The CHRONICLE Study is a multi-center, non-interventional, prospective cohort study of adults with severe asthma who do not achieve control with high-dose inhaled corticosteroid (ICS) therapy

  • 24 Oct, 2022
  • 92 locations
Cryptococcosis in Previously Healthy Adults

culture of Cryptococcus neoformans 18 years of age and older without HIV infection or other condition predisposing to cryptococcosis (such as high-dose corticosteroid therapy, sarcoidosis, or a blood

Accepts healthy volunteers
  • 27 Oct, 2022
  • 1 location
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

activities, such as walking and the loss of muscle strength. In a small group of subjects the investigators will also assess the effect of corticosteroid drugs on the muscle measurements.

creatine kinase
becker muscular dystrophy
muscle damage
serum creatine
  • 22 Jul, 2021
  • 3 locations
Data Registry of Auto Immune Hemolytic Anemia (DRAIHA)

to inhibit autoantibody production and/or RBC destruction. Many patients do not respond adequately to corticosteroid treatment or develop severe side effects. Currently, it is advised to

Accepts healthy volunteers
  • 12 Feb, 2022
  • 1 location
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

off. Participants who have a joint aspiration may provide a fluid sample. The joint will be prepared, then fluid is removed by needle. A corticosteroid may be injected.

Accepts healthy volunteers
  • 07 Oct, 2022
  • 1 location
Natural History of Hypereosinophilia and Hypereosinophilic Syndromes (COHESION)

Unexplained chronic hypereosinophilia (HE) and hypereosinophilic syndromes (HES) are heterogeneous regarding the organ involvements (heart, lungs, skin, .. or none), the evolutionary profiles, the response to treatments. Underlying mechanisms are largely unknown and may associate genetic predisposing factors (germinal ? somatic?), environmental factors (alimentation, tobacco use, hormones, infections, ..) The …

  • 12 Feb, 2022
Longitudinal Observational Study of Severe Asthma

Background Asthma is a lung condition that causes difficulty breathing and decreased lung function. Some people with asthma have more severe disease symptoms. They may be less responsive to standard treatments such as steroids. Researchers want to compare severe asthmatics with mild or moderate asthmatics or people without asthma over …

obstructive lung disease
airways disease
Accepts healthy volunteers
pulmonary function test
  • 20 Oct, 2022
  • 1 location
Metabolic Syndrome and Persistent Shoulder Pain 1 Year After Primary Diagnosis

In a longitudinal cohort project, the objective is to evaluate general prognostic and individual risk factors for long lasting shoulder pain, with a specific focus on evaluation of the association between metabolic syndrome and tendinopathy, while simultaneous adjusting for other potential prognostic candidate variables (PROGRESS Theme I-II).

  • 11 Mar, 2021
  • 1 location
Hydroxychloroquine in Systemic Lupus Erythematosus

A Systemic lupus erythematosus, SLE is disease in which immune system is over-active causing inflammation in joints skin or any organ system. There are many areas where better approaches in SLE could improve outcomes. One example relates to hydroxychloroquine (HCQ) key drug which can reduce risk of serious disease flares. …

  • 22 Jan, 2021
  • 1 location