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Found 290 clinical trials
Featured trial
A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft Versus-Host Disease

A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft Versus-Host Disease

stem cell transplantation
bone marrow transplant
nutritional supplement
transplant conditioning
stem cell transplant
  • 322 views
  • 08 Dec, 2020
  • 1 location
Hydrocortisone and Fludrocortisone for Critical Illness-related Corticosteroid Insufficiency (HORNbILL)

The study aims at assessing the efficacy and the safety of hydrocortisone combined with fludrocortisone compared to placebo in ICU adults with critical illness related corticosteroid

  • 0 views
  • 21 Mar, 2022
Eosinophil-driven Corticotherapy for Patients Hospitalized for COPD Exacerbation (eo-Drive)

recovery during the initial hospitalization; corticosteroid side effects / induced comorbidities; changes in symptoms and episodes of exacerbation; pulmonary function, oxygen

  • 0 views
  • 03 Jul, 2022
  • 9 locations
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab. (MANDARA)

administered by subcutaneous (SC) injection in patients with relapsing or refractory EGPA on corticosteroid therapy with or without stable immunosuppressive therapy. All patients who complete the 52

corticosteroid therapy
immunosuppressive agents
purpura
immunosuppression
steroid therapy
  • 65 views
  • 28 Jul, 2022
  • 70 locations
A Study to Evaluate the Efficacy and Safety of BIIB059 in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Nonbiologic Lupus Standard of Care (TOPAZ-2)

receiving background lupus SOC therapy in reducing joint disease activity; to demonstrate effect of BIIB059 compared with placebo in reducing oral corticosteroid(s) (OCS) use; to demonstrate organ-specific

antimalarials
rheumatism
  • 40 views
  • 14 May, 2022
  • 33 locations
Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD) (AERIFY-1)

compared with placebo on severe AECOPD in former smokers with moderate-to-severe COPD Evaluate the efficacy of itepekimab compared with placebo on corticosteroid-treated AECOPD in former smokers

  • 5 views
  • 15 Jul, 2022
  • 124 locations
A Study to Evaluate the Efficacy and Safety of BIIB059 in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Nonbiologic Lupus Standard of Care (TOPAZ-1)

receiving background lupus SOC therapy in reducing joint disease activity; to demonstrate effect of BIIB059 compared with placebo in reducing oral corticosteroid (OCS) use; to demonstrate organ-specific

antimalarials
rheumatism
  • 3 views
  • 13 May, 2022
  • 35 locations
Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions (DEXA-REFINE)

Background: There are no proven therapies specific for pulmonary dysfunction in patients with acute hypoxemic respiratory failure (AHRF) caused by infections (including Covid-19). The full spectrum of AHRF ranges from mild respiratory tract illness to severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure, and death. The efficacy of corticosteroids …

  • 0 views
  • 10 Apr, 2022
Benefit of a Flash Dose of Corticosteroids in Digestive Surgical Oncology: a Randomized, Double Blind, Placebo-controlled Trial (CORTIFRENCH)

Perioperative inflammation is harmful in cancer patients, namely in those undergoing surgery: it increases the risk of recurrence, decreases cancer survival, increases post-operative complications, and prolongs the time of recovery and the duration of hospital stay. Severe postoperative complications are also a risk factor of poor survival in cancer patients. …

  • 0 views
  • 15 Mar, 2022
  • 1 location
Dual-target Ultrasound Guided Corticosteroid Injection for Shoulder Impingement Syndrome

subacromial injection. In this regard, the investigators will conduct a longitudinal follow-up study to examine the long-term effectiveness of the dual-target corticosteroid injection for subacromial

  • 0 views
  • 26 Jan, 2021
  • 1 location