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Found 39 clinical trials
Featured trial
Longitudinal Observational Study of Severe Asthma

Background: Asthma is a lung condition that causes difficulty breathing and decreased lung function. Some people with asthma have more severe disease symptoms. They may be less responsive to standard treatments such as steroids. Researchers want to compare severe asthmatics with mild or moderate asthmatics or people without asthma over …

asthmatic
allergic asthma
asthma
  • 22 views
  • 22 Dec, 2020
  • 1 location
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab. (MANDARA)

administered by subcutaneous (SC) injection in patients with relapsing or refractory EGPA on corticosteroid therapy with or without stable immunosuppressive therapy. All patients who complete the 52

asthma
anca
steroid therapy
mepolizumab
oral prednisolone
  • 65 views
  • 28 Jul, 2022
  • 70 locations
Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions (DEXA-REFINE)

Background: There are no proven therapies specific for pulmonary dysfunction in patients with acute hypoxemic respiratory failure (AHRF) caused by infections (including Covid-19). The full spectrum of AHRF ranges from mild respiratory tract illness to severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure, and death. The efficacy of corticosteroids …

  • 0 views
  • 10 Apr, 2022
Evaluation of a Nurse-led Program for the Prevention of Complications of Long-term Corticosteroid Therapy (COCORTICO)

Long term corticosteroid therapy concerns 0.5 to 1% of the population and about 2.5% of elderly subjects. It is currently used as a cornerstone therapy in a wide variety of clinical contexts

  • 0 views
  • 15 May, 2022
  • 1 location
Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock. (COCCA)

The purpose of this randomized controlled trial is to evaluate the hemodynamic effect of low dose corticosteroid therapy (hydrocortisone and fludrocortisone) in the treatment of adult

pulmonary artery occlusion
catecholamines
congestion
oliguria
pulmonary congestion
  • 24 views
  • 30 Jun, 2022
  • 12 locations
Ustekinumab for the Treatment of Relapse of Refractory Giant Cell Arteritis (ULTRA)

patients with GCA will relapse during their follow-up. Thus, the vast majority of patients treated for GCA have at least one adverse event from corticosteroid therapy, which is the main source of morbidity

  • 0 views
  • 29 May, 2022
  • 1 location
Study of T Lymphocytes in Patients With Horton Disease (GAMAIT)

Giant-cell arteritis (GCA) is the most frequent vasculitis after 50 years. Corticosteroid therapy is the reference treatment for GCA. This treatment is highly effective but must be maintained

inflammatory disease
temporal artery biopsy
headache
cancer
corticosteroids
  • 1 views
  • 04 Mar, 2022
  • 1 location
A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) (USTEKINISU)

side effects of chronic corticosteroid therapy and better understanding of the mechanisms of autoimmune-mediated uveitis, the aim of the treatment for patients with noninfectious uveitis is steroid

  • 24 views
  • 15 Feb, 2022
  • 3 locations
Effects of Anakinra in Subjects With Autoimmune Inner Ear Disease

A Phase II randomized, placebo controlled study design of anakinra (Kineret) in corticosteroid-resistant Meniere's disease (CR-MD)and corticosteroid-resistant autoimmune inner ear disease (CR-AIED) patients. Patients will be randomized by a 2:1 allocation to anakinra or placebo for 42 continuous days. After day 42, a second placebo-controlled period will begin for an …

  • 26 views
  • 14 Feb, 2022
  • 1 location
Cervical Occlusion Two-level Stitch Application (COSA)

Cervical insufficiency is defined as painless dilatation of the cervix during the second trimester of pregnancy. As a result of shortening and opening of the cervix, despite the lack of uterine contractions, the fetal membranes invade into the cervical canal and then into the vagina, which results in premature rupture …

  • 0 views
  • 23 Jul, 2022
  • 3 locations