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Found 46 clinical trials
Study of Efficacy and Safety of Brolucizumab Versus Panretinal Photocoagulation Laser in Patients With Proliferative Diabetic Retinopathy

). This evaluation will provide information that brolucizumab is non-inferior to PRP with respect to the change in best corrected visual acuity at Week 54.

  • 13 May, 2022
  • 76 locations
Phase III Study Assessing the Efficacy, Safety and Immunogenicity of SOK583A1 Versus Eylea® in Patients With Neovascular Age-related Macular Degeneration (Mylight)

Purpose and rationale: To demonstrate similar efficacy, safety and immunogenicity of SOK583A1 and Eylea EU as per Eylea approved treatment regimen in patients with nAMD. The primary clinical question of interest is: Does SOK583A1 have similar efficacy as Eylea EU in terms of mean change in BCVA score in participants …

  • 02 May, 2022
  • 105 locations
Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema

> Subjects will be evaluated every month for safety, efficacy as measured by SDOCT and best corrected visual acuity (BCVA) using the Electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS

edema secondary
diabetic retinopathy
corrected visual acuity
  • 31 Jul, 2021
  • 1 location
A Study to Evaluate the Safety and Tolerability of EXN407

in subjects with centre involved Diabetic Macular Oedema (DMO), with Centre-subfield macular thickness (CMT) between 280-420 µm and Best corrected visual acuity (BCVA) better than or equal to 69

  • 25 Mar, 2022
  • 11 locations
Binocular Visual Therapy and Video Games for Amblyopia Treatment.

Amblyopia, or lazy eye, is best defined by the American Academy of Ophthalmology as a unilateral or bilateral reduction of the best corrected visual acuity that occurs in the setting of an

corrected visual acuity
strabismic amblyopia
isometropic amblyopia
  • 15 Feb, 2022
  • 1 location
Initial Correction Keratoconus

Keratoconus is a non-inflammatory, progressive disease in which corneal irregularity increases. As the condition develops, more advanced forms of optical correction are needed to improve vision for patients. Until recently, small diameter corneal gas permeable lenses were considered the primary mode of correction for patients with keratoconus. Now, however, practitioners …

  • 17 Nov, 2021
  • 3 locations
Micropulsed Laser Trabeculoplasty Using Different Parameters

This randomized, double blinded, clinical trial compares two different parameters setting of micropulsed laser trabeculoplasty for open angle glaucoma. Group one is treated with 1500 mW of Power, Group two with 1000 mW. The other settings (300 micron of diameter, 300 ms of duration, 15% duty cycle) are the same …

brimonidine tartrate ophthalmic solution
primary open angle glaucoma
intraocular pressure
laser trabeculoplasty
  • 30 May, 2021
  • 1 location
Clinical Study of Transplanting Human Retinal Pigment Epithelial Cells for Treatment of Macular Degeneration

This study is an open-label investigation of the safety and preliminary efficacy of the subretinal transplantation of human retinal pigment epithelial cells on Macular Degeneration.

retinal pigment
  • 08 Nov, 2020
  • 1 location
Micropulse for Suppression of Diabetic Macular Edema (PULSE)

Diabetic retinopathy is one of the most common complications of diabetes and diabetic macular edema (DME) is one of the most common causes of vision loss in diabetes. The purpose of this study is to determine if early intervention with micropulse laser treatment in eyes with good visual acuity (20/32 …

diabetic retinopathy
corrected visual acuity
type 2 diabetes mellitus
  • 23 Mar, 2022
  • 1 location
Treatment of Central Retinal Vein Occlusion Using Stem Cells Study (TRUST)

This study evaluates whether intravitreal autologous CD34+ stem cell therapy is safe, feasible and potentially beneficial in eyes with vision loss from central retinal vein occlusion (CRVO). Half of the participants will receive immediate cellular therapy followed by sham therapy 6 months later, while the other half will receive immediate …

stem cell therapy
venous obstruction
sham therapy
  • 11 Feb, 2022
  • 1 location