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Found 107 clinical trials
The OPTIMAL Randomized Controlled Trial

The OPTIMAL study is a randomized, controlled, multicentre, international study. A total of 800 patients will be randomized in a 1:1 fashion to Intravascular Ultrasound (IVUS)-guided PCI versus qualitative angio(QCA)-guided Percutaneous Coronary Intervention (PCI). Patients will be consented prior to the PCI procedure and then followed up to 2 years …

  • 0 views
  • 27 Jan, 2021
  • 30 locations
Evaluation of a New Nanotechnology Based Drug-Eluting Stent for Opening of Narrowed Arteries of the Heart

Coronary artery disease (CAD) is the largest cause of death and disability in the world. Besides medicines, the principle treatment of this condition requires opening of the narrowed arteries, responsible for angina and other symptoms of the disease, by angioplasty or surgery. Introduction of metal scaffolds called 'stents' in the …

diabetes
angina pectoris
chest pain
angiography
ischemia
  • 24 views
  • 07 Nov, 2020
  • 1 location
Compare the Efficacy and Safety of Genoss DCB and SeQuent Please in Chinese Patients With Coronary In-stent Restenosis

This trial is a prospective, multicenter, randomized, non inferiority design clinical trial with 224 eligible subjects in about 15 research centers nationwide. After the informed consent was signed, the patients were screened. The patients who met all the inclusion criteria and did not meet any of the exclusion criteria were …

  • 0 views
  • 07 Mar, 2021
  • 1 location
A Study to Evaluate Direct Wire Pacing (DWP) for Measuring Fractional Flow Reserve (FFR)

indications. All subjects requiring on a clinical basis a pressure wire assessment of coronary artery stenosis(es) will be eligible to take part in the study.

  • 0 views
  • 31 Jul, 2021
  • 1 location
Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease

mortality and morbidity in SLE.Previous research has shown that 35-40% of patients with SLE have abnormalities of myocardial perfusion even when they have no coronary stenoses on coronary

heart disease
ace inhibitor
cardiovascular disease
autoimmune disease
  • 27 views
  • 07 Nov, 2020
  • 1 location
Less Invasive Detection and Treatment of Very Early Coronary Artery Disease in Patients With Diabetes Mellitus

This protocol focuses on the development of a noninvasive method of early coronary artery disease detection in diabetes. The overall hypothesis is that risk factors for the metabolic syndrome will predict invasive findings on intravascular ultrasound (IVUS) and noninvasive findings on cardiac magnetic resonance (CMR) perfusion imaging. Secondary objectives will …

metabolic syndrome
  • 15 views
  • 07 Nov, 2020
  • 1 location
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy (HOST-IDEA) Trial

We had little experience in coronary intervention with recently introduced newer drug-eluting stent (DES) platforms, despite great anticipation, and optimal duration of dual antiplatelet therapy (DAPT) for these stent systems still needs to be established. With a 2x2 factorial design for patients of stable angina or silent ischemia, the investigators …

coronary artery stenosis
stenotic
dapt
stenosis
antiplatelet therapy
  • 0 views
  • 21 Jan, 2021
  • 7 locations
TAILored Versus COnventional AntithRombotic StratEgy IntenDed for Complex HIgh-Risk PCI

This study evaluates the efficacy and safety of tailored antithrombotic therapy with early (<6-month post-PCI) intensified (low-dose ticagrelor [120 mg loading, then 60 mg bid maintenance] and aspirin) and late (>6-month post-PCI) deescalated (clopidogrel alone) strategy in patients undergoing high-risk complex PCI as compared with standard Dual Antiplatelet Therapy(aspirin and …

diabetes
aspirin
percutaneous coronary intervention
  • 7 views
  • 02 Aug, 2021
  • 16 locations
Saline-induced Distal to Aortic Coronary Pressure Ratio vs. Resting and Hyperemic Indices of Coronary Artery Stenosis Severity

The presence of inducible myocardial ischemia is considered as the prerequisite for the clinical benefit of coronary revascularization. In this regard, the introduction of invasive pressure-derived physiological indices to guide myocardial revascularization represented a major breakthrough for the treatment of patients with coronary artery disease (CAD), by moving the focus …

stemi
vasodilator
physiological assessment
adenosine
ischemia
  • 0 views
  • 10 May, 2021
  • 1 location
Comparison of Vessel-FFR Versus FFR in Intermediate Coronary Stenoses

This is a prospective, randomized, controlled, multicenter, open-label study designed to assess whether vFFR is non-inferior to FFR in assessment of intermediate coronary stenosis in terms of

coronary artery stenosis
arterial disease
stenosis
stable angina
stemi
  • 0 views
  • 25 Jan, 2021
  • 1 location