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Found 17 clinical trials
Descemet Endothelial Thickness Comparison Trial I (DETECT I)

purpose of this study is to determine differences in visual outcomes between two types of corneal transplant surgeries, ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and

  • 0 views
  • 04 Oct, 2022
  • 4 locations
Deep Anterior Lamellar Keratoplasty Using Dehydrated Versus Standard Organ Culture Stored Donor Corneas

The objective of this study is to assess the outcomes between deep anterior lamellar keratoplasty using dehydrated versus standard organ culture stored donor corneas.

corneal transplant
lamellar keratoplasty
  • 0 views
  • 24 Jan, 2021
  • 1 location
Evaluation of Safety and Efficacy of a Bioengineered Corneal Implant for Treatment of Keratoconus (LinkCor)

This is a prospective, Phase I open-label safety study to evaluate the safety, feasibility and initial efficacy of a bioengineered corneal stromal substitute after implantation into the stroma of adults with advanced keratoconus. The bioengineered substitute and implantation technique may provide a less invasive treatment option for advanced keratoconus than …

Accepts healthy volunteers
  • 0 views
  • 14 Jun, 2022
  • 2 locations
Initial Correction Keratoconus

Keratoconus is a non-inflammatory, progressive disease in which corneal irregularity increases. As the condition develops, more advanced forms of optical correction are needed to improve vision for patients. Until recently, small diameter corneal gas permeable lenses were considered the primary mode of correction for patients with keratoconus. Now, however, practitioners …

  • 0 views
  • 03 Jun, 2022
  • 4 locations
Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting (CXL-KPro)

The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston keratoprosthesis (KPro) type I against corneal melting (keratolysis or sterile necrosis).

  • 23 views
  • 04 Oct, 2022
  • 1 location
Diabetes Endothelial Keratoplasty Study (DEKS): Impact of Diabetes on Corneal Transplant Success and Endothelial Cell Loss (DEKS)

This double-masked multi-center trial will evaluate the association of diabetes in the cornea donor with transplant success and loss of endothelial cells one year following Descemet membrane endothelial keratoplasty (DMEK). Study eyes will be assigned to receive either a cornea from a donor without diabetes or a cornea from a …

  • 0 views
  • 29 Oct, 2022
  • 2 locations
First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness

Prospective, open label, single arm, First in Human (FIH) clinical study to assess safety and efficacy of the CorNeat Keratoprosthesis, a synthetic cornea, for the treatment of corneal blindness

  • 0 views
  • 15 May, 2022
  • 6 locations
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears) (AH-Tears)

Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation. High intraocular pressure (IOP) is the most important risk factor for glaucoma and may lead to irreversible retinal and optic nerve damage. Glaucoma drainage device (GDD) surgery is used to divert aqueous …

cataract
Accepts healthy volunteers
aqueous humor
glaucoma
drainage
  • 0 views
  • 04 Oct, 2022
  • 1 location
Clinical Study on the Treatment of Mixed Component Cornea for High Risk Keratoplasty

neovascularization after ocular trauma or infection, the graft rejection rate is more than 65%, it is called high-risk keratoplasty. This study will observe the graft survival of high-risk corneal

  • 0 views
  • 08 Mar, 2022
  • 1 location
Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema

and vision loss are not controlled by topical treatment, the only option is a corneal transplant. A potential approach to avoidance of the risks of corneal transplantation is to inject cultured human

  • 0 views
  • 07 Oct, 2022
  • 6 locations