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Found 25 clinical trials
Three Fraction Radiation to Induce Immuno-Oncologic Response

Patients with high risk breast cancers (any locally advanced breast cancer patient defined as Stages IIB-III [excluding inflammatory breast cancer] with stage IIA being eligible for triple negative and HER2-positive breast cancers) will receive neoadjuvant radiation to any portion of their tumour in three fractions in order to act as …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Comparison Trial of Open-tip Pulsed Needle Biopsy and Conventional Core Biopsy in Axillary Lymph Nodes

The aim of the study is to compare performance and safety of a newly developed 14-gauge open-tip pulsed biopsy needle with a conventional 14-gauge core biopsy needle for sampling of radiologically indeterminate or suspicious axillary lymph nodes in women with radiologically suspected breast cancer. This is a Sponsor-initiated multicentre randomised …

metastasis
core needle biopsy
breast carcinoma
  • 15 views
  • 25 Jan, 2021
  • 9 locations
Evaluating the Efficacy of Neratinib on Live Cell HER2 Signaling Transduction Analysis Positive Triple Negative Breast

An Open-Label Phase II Trial to Evaluate the Efficacy and Safety of Neoadjuvant Neratinib Followed by Weekly Paclitaxel and Carboplatin Plus Neratinib in Early Stage Triple-Negative Breast Cancer Patients Who Exhibit Enhanced HER2 Signaling by Live Cell HER2 Signaling Transduction Analysis (FACT-2)

breast cancer
ejection fraction
adenocarcinoma of the breast
immunohistochemistry
estrogen
  • 0 views
  • 25 Jan, 2021
  • 1 location
Selective Treatment According to Molecular Subtype of Prostate Cancer

This is an open-label study that includes three substudies of random distribution. First, a sample of the primary tumor will be obtained and will be analyzed by an immunohistochemical technique to determine several markers. Depending on the expression of these markers, the patients will be characterize as group 1 (Luminal …

testosterone
serum testosterone
  • 1 views
  • 22 Jan, 2021
  • 1 location
Systems Biology of Inactivated Rabies Vaccine in Healthy Adults With or Without Use of Broad Spectrum Antibiotics

The study is a prospective randomized, unblinded study looking to enroll 54 subjects at Emory University. The use of antibiotics changes micro-organisms in the intestines. The change to micro-organisms in the intestines may change the body's vaccine immune response and alter the effectiveness of the rabies vaccine. There will be …

  • 29 views
  • 25 Jan, 2021
  • 2 locations
GCC 1366: Anti-Proliferative Response to NeoAdjuvant AIs in Overweight and Obese Patients

More than three quarter of patients with breast cancer are treated by hormone pills called tamoxifen and aromatase inhibitors (AIs). AIs are drugs that stop female hormone production. This hormone production mostly happens in fat, muscle, and breast tissue in postmenopausal women. The female hormone estrogen is an important hormone …

letrozole
estrogen
erbb2
endocrine therapy
arimidex
  • 19 views
  • 23 Jan, 2021
  • 1 location
A Multicenter Clinical Trial of Daratumumab in Combination With Gemcitabine Dexamethasone and Cisplatin in Patients With Relapsed/Refractory CD38 Positive PTCL-NOS Angioimmunoblastic T-cell Lymphoma AITL and Other Nodal Lymphomas of T Follicular Helper Cells Origin

FIL_Dara-GDP is a phase II, open label, multicenter clinical trial. The sponsor of this clinical trial is Fondazione Italiana Linfomi (FIL). The primary objective is to evaluate the efficacy of 4 courses of D-GDP (Daratumumab in combination with Gemcitabine, Cisplatin, Dexamethasone) in terms of complete response in patients with peripheral …

  • 0 views
  • 27 Mar, 2021
  • 20 locations
The Diagnosis and Prognosis of Nonpalpable Breast Cancer Detected by the US vs Mammography: a Clinical Noninferiority Trial.

To evaluate and compare the sensitivity, specificity, AUC, pathology results of core needle biopsy and surgical pathology results coincidence rate, tumor staging, and DFS (disease-free survival

mammogram
breast imaging reporting and data system
core needle biopsy
breast carcinoma
  • 0 views
  • 24 Jan, 2021
  • 1 location
Identification of Clinically Insignificant or Significant Prostate Cancer With the miR Scientific Sentinel Platform

clinical data with the study team. Participants, between the age of 50 and 80 years with suspicion of prostate cancer for whom a core-needle biopsy is performed, and otherwise meeting the inclusion

  • 2 views
  • 25 Jan, 2021
  • 3 locations
Assessment of Complete Pathologic Response After Neoadjuvant Chemotherapy for Breast Cancer

This is a feasibility study to gain preliminary information regarding whether breast imaging with or without a core needle biopsy after neoadjuvant chemotherapy (NAC) but before surgery can

breast cancer
cancer
core needle biopsy
ductal carcinoma in situ
carcinoma in situ
  • 0 views
  • 25 Jan, 2021
  • 1 location